Document Detail

Response to atrial natriuretic peptide in dogs with acute selective intrahepatic hypertension.
MedLine Citation:
PMID:  2533478     Owner:  NLM     Status:  MEDLINE    
Acute selective intrahepatic hypertension (IHH) is associated with the renal tubular retention of sodium in volume expanded dogs. To determine if acute selective IHH per se, without volume loading or ascites sequestration, would blunt the natriuretic response to i.v. infusions of atrial natriuretic peptide (ANP), 175 ng/kg/min of the 1-28 rat peptide was infused into 6 hydropaenic dogs where intrahepatic hydrostatic pressures were normal, and again, following the portal infusion of histamine, a maneuver known to selectively increase postsinusoidal resistance, within the hepatic microcirculation and so raise intrahepatic sinusoidal pressure. In 6 healthy dogs, while histamine 4.0 micrograms/min free base on average was being infused into a femoral vein, the infusion of ANP increased sodium excretion by 168 microEq/min, compared to 160 microEq/min when the same dose of histamine was being infused into the portal vein (portal pressure increased by 46% or 6 cm H2O). These changes in sodium excretion were not significantly different. Urine flow rate increased by 1.5 ml/min in the control phase and by 1.4 ml/min during intrahepatic hypertension (NS). Although the ANP infusion did not alter GFR or CPAH during the control phase, during IHH, ANP caused GFR to rise significantly by 20%, while there was no change to CPAH. Despite the increment in GFR, the natriuretic response during IHH was not different from that observed during the control phase of the study. We conclude that acute IHH per se does not blunt the renal tubular natriuretic response to ANP.
E Maher; M Levy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  300     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:    1989 Jul-Aug
Date Detail:
Created Date:  1990-03-06     Completed Date:  1990-03-06     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  231-40     Citation Subset:  IM    
Department of Physiology, McGill University, Montreal, Canada.
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MeSH Terms
Atrial Natriuretic Factor / pharmacology*
Central Venous Pressure / drug effects
Glomerular Filtration Rate / drug effects
Histamine / pharmacology
Hypertension / physiopathology*
Kidney / physiopathology
Liver Circulation / drug effects
Natriuresis / drug effects
Renal Circulation / drug effects
Reg. No./Substance:
51-45-6/Histamine; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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