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Response to X-radiation and cytotoxic drugs of clonal subpopulations of different ploidy and metastatic potential isolated from RIF-1 mouse sarcoma.
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MedLine Citation:
PMID:  6860550     Owner:  NLM     Status:  MEDLINE    
Clonal subpopulations of different ploidy values and metastatic capacities, isolated from the RIF-1 mouse sarcoma, have been tested for in vitro X-radiation sensitivity, for in vitro sensitivity to adriamycin and for in vitro and in vivo sensitivity to melphalan and CCNU. Following X-radiation, no consistent differences in the survival curve characteristics (Do and n) of diploid, tetraploid and octoploid cells were observed. In addition no relationship between radiation response and metastatic capacity was observed. For drug response, no marked differences were found in the dose response curves of RIF-1 clones treated in vitro with adriamycin. However, a wide variation in the responses of RIF-1 clones to in vitro melphalan treatment was observed which was independent of both ploidy and metastatic capacity. Although the responses of RIF-1 clones to in vitro CCNU treatment were similarly independent of metastatic capacity, a clear relationship between CCNU sensitivity and ploidy was observed. Thus, all diploid RIF-1 clones were markedly more sensitive to CCNU treatment than either tetraploid or octoploid RIF-1 clones. For both melphalan and CCNU treatment the relative sensitivities in vitro correlated with in vivo sensitivities as assayed by clonogenic cell survival.
J G Reeve; K A Wright; P R Twentyman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of cancer     Volume:  47     ISSN:  0007-0920     ISO Abbreviation:  Br. J. Cancer     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370635     Medline TA:  Br J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  841-8     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / pharmacology*
Cell Line
Cell Survival / drug effects,  radiation effects
Clone Cells / drug effects,  radiation effects
Dose-Response Relationship, Drug
Doxorubicin / pharmacology
Lomustine / pharmacology
Melphalan / pharmacology
Mice, Inbred C3H
Sarcoma, Experimental / pathology*,  secondary
Reg. No./Substance:
0/Antineoplastic Agents; 13010-47-4/Lomustine; 148-82-3/Melphalan; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Br J Cancer
ISSN: 0007-0920
ISSN: 1532-1827
Article Information
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Print publication date: Month: 6 Year: 1983
Volume: 47 Issue: 6
First Page: 841 Last Page: 848
ID: 2011365
PubMed Id: 6860550

Response to X-radiation and cytotoxic drugs of clonal subpopulations of different ploidy and metastatic potential isolated from RIF-1 mouse sarcoma.
J. G. Reeve
K. A. Wright
P. R. Twentyman

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  • Research Article

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