Document Detail

Response of the systemic and pulmonary circulation to converting-enzyme inhibition (captopril) at rest and during exercise in hypertensive patients.
MedLine Citation:
PMID:  6273009     Owner:  NLM     Status:  MEDLINE    
Twenty sodium-replete patients with hypertension were allocated either to a placebo or to a captopril treatment group. Each patient was investigated in rest-recumbent (RR) and rest-sitting (RS) positions and during an uninterrupted, graded, submaximal exercise test (up to the anaerobic threshold) before treatment, and with a similar protocol 75 minutes after treatment with captopril or placebo on the same morning. Captopril decreased brachial intraarterial pressure by 7/4 mm Hg at RR, by 16/10 mm Hg at RS, and by 19/10 mm Hg during exercise (p less than 0.001), based on a decrease of systemic vascular resistance (p less than 0.001). Slight increases of cardiac output and of heart rate were noted at rest; cardiac output was not significantly affected during exercise, but the increase of heart rate of 2.4 beats/min was significant (p less than 0.01). Captopril decreased pulmonary artery (p less than 0.05) and capillary wedge pressures (p less than 0.001), with unchanged pulmonary vascular resistance. The data indicate that the action of captopril is characterized by arteriolar and possibly venous dilatation both at rest and during exercise. Pulmonary vascular resistance, however, is not affected.
R Fagard; C Bulpitt; P Lijnen; A Amery
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  65     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-02-25     Completed Date:  1982-02-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-9     Citation Subset:  AIM; IM; S    
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors*
Blood Pressure / drug effects
Captopril / therapeutic use*
Hemodynamics / drug effects
Hypertension / drug therapy*
Physical Exertion
Proline / analogs & derivatives*
Pulmonary Circulation / drug effects*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 147-85-3/Proline; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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