| Response of sympathetic nervous system activity to exercise in patients with congestive heart failure. | |
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MedLine Citation:
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PMID: 1752293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the serial sympathetic nervous system response to exercise, plasma norepinephrine (NE) and epinephrine (E) concentrations were measured at rest, during each stage of treadmill exercise, and immediately and 5 minutes after exercise in 68 congestive heart failure (CHF) patients (NYHA functional class I 24, II 25, III 19) and 30 normal subjects. Circulatory responses of NYHA class II patients increased at early stages of exercise. Systolic blood pressure and double product at peak exercise were significantly lower in NYHA class III patients. Plasma NE response of NYHA class I patients was similar to that of normal subjects. However, plasma NE at rest, and during and after exercise were significantly higher in NYHA classes II and III patients than in normal subjects and NYHA class I patients (peak NE (pg ml-1); Normals: 547 +/- 37, I: 535 +/- 53, II: 867 +/- 87, III: 1033 +/- 157). There was no significant difference in plasma E levels among the four groups. NE response to exercise was augmented according to the severity of heart failure, which suggested compensatory activation of sympathetic nervous system activity. Circulatory responses were reduced in NYHA class III patients despite the exaggerated compensatory activation of the sympathetic nervous system. Blunted circulatory responses to increased NE concentration in NYHA class III patients might relate to a decreased cardiac responsiveness to sympathetic activity in severe CHF patients. |
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Authors:
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T Kinugawa; K Ogino; H Kitamura; H Miyakoda; M Saitoh; J Hasegawa; H Kotake; H Mashiba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical investigation Volume: 21 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1992-01-27 Completed Date: 1992-01-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 542-7 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure Epinephrine / blood Exercise / physiology* Female Heart Failure / blood, physiopathology* Heart Rate Humans Male Middle Aged Norepinephrine / blood Sympathetic Nervous System / physiopathology* |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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