| Response of solitary psoriatic plaques to experimental application of podophyllotoxin. | |
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MedLine Citation:
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PMID: 3525264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 16-week double-blind study of parallel groups was carried out in the treatment of 152 patients suffering from stable psoriasis vulgaris. Podophyllotoxin was applied once daily at three different concentrations in an ointment base, namely 0.1, 0.25 and 0.5%. One stable psoriatic lesion was selected and monitored during the study course. All three concentrations of podophyllotoxin induced a statistically highly significant improvement (p less than 0.001) of the selected lesions. There was statistically highly significant difference between the treated and control lesions already after 2 weeks of treatment (p greater than 0.001), and this difference increased further during the study course. Eleven patients experienced adverse reactions - severe skin rash - spontaneously reported by the patients. |
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Authors:
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A Lassus; B Rosen |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Dermatologica Volume: 172 ISSN: 0011-9075 ISO Abbreviation: Dermatologica Publication Date: 1986 |
Date Detail:
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Created Date: 1986-09-25 Completed Date: 1986-09-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0211607 Medline TA: Dermatologica Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 319-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Clinical Trials as Topic Double-Blind Method Female Humans Male Middle Aged Podophyllotoxin / therapeutic use* Psoriasis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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518-28-5/Podophyllotoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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