| Response rate of Pakistani children with acute lymphoblastic leukaemia to Medical Research Council acute lymphoblastic leukaemia 97 chemotherapy protocol. | |
| | |
MedLine Citation:
|
PMID: 22338406 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: Acute lymphoblastic leukaemia (ALL), a malignancy of lymphoid lineage cells, has excellent prognosis in children. In Pakistan, a few studies highlighted the response of ALL to chemotherapy. The Present study was planned to see the response rate of Pakistani children with ALL to Medical Research Council ALL 97 (MRCALL97) chemotherapy protocol. This descriptive case series was conducted at the Department of Haematology, Armed Forces Institute of Pathology and the Department of Paediatric Oncology, Combined Military Hospital, Rawalpindi from 16th of February 2007 to 16th of August 2007. METHODS: Diagnosed children with ALL fulfilling the inclusion criteria were interviewed regarding history of the present, past illnesses, and family history. Physical examination was performed. Presenting clinical features, blood counts and blood and bone marrow blasts percentage were used to see the response on day 29 post chemotherapy. The data was recorded on a structured proforma for statistical analysis. RESULTS: A total of 33 patients were studied including 26 males and 7 females. Twenty-five patients belonged to age group 2-9 years, and 8 to < 2 or > 9 years, median age being 4.5 years. Presenting WBC count was < 50 x 10(9)/L in 30 patients and > 50 x 10(9)/L in 3 patients. At the end of induction, complete remission was achieved in 31 out of 33 (94%) patients while two patients did not achieve remission. CONCLUSION: Response rate of Pakistani children with ALL to chemotherapy was superior to the previously reported figures from Pakistan. |
| | |
Authors:
|
Muhammad Idris; Jamila Farid; Javed Sarwar; Suhaib Ahmed; Muhammad Amin Wiqar; Shahida Badsha |
Related Documents
:
|
453296 - Further observations on the effect of topical progesterone on vulvar disease. 22313936 - Effects of neonatal enteral glutamine supplementation on cognitive, motor and behaviour... 22716216 - Back mobility and interincisor distance ranges in racially diverse north american healt... 22763596 - Association between glucan synthesis by streptococcus mutans and caries incidence in sc... 2607396 - Behavioral adjustment of pediatric burn victims. 23222406 - The long-term outcome of retained foreign bodies in pediatric gunshot wounds. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of Ayub Medical College, Abbottabad : JAMC Volume: 22 ISSN: 1025-9589 ISO Abbreviation: J Ayub Med Coll Abbottabad Publication Date: 2010 Jul-Sep |
Date Detail:
|
Created Date: 2012-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8910750 Medline TA: J Ayub Med Coll Abbottabad Country: Pakistan |
Other Details:
|
Languages: eng Pagination: 8-11 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Ayub Medical College, Abbottabad, Pakistan. midris63@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Zoledronic acid in metastatic bone disease: an audit based discussion.
Next Document: Empyema thoracis: management outcome.