| Response of rat jejunum to changes in sodium and volume balance. | |
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MedLine Citation:
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PMID: 3019157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Initial studies determined whether a renal factor facilitates decreased jejunal absorption following volume expansion of the anesthetized rat. Volume expansion (VE) decreased jejunal absorption to the same extent in both normal and nephrectomized animals. Furthermore, VE of a donor animal failed to alter jejunal absorption in a recipient following cross circulation. Thus, a hormonal factor is not implicated in the jejunal response to VE. Additional experiments demonstrated that rats ingesting a high-Na diet exhibited levels of jejunal absorption lower than animals fed a normal-Na diet. High-Na animals were not volume expanded. Plasma aldosterone concentrations and plasma renin activity were reduced in high-Na animals. Bilateral adrenalectomy-nephrectomy inhibited jejunal absorption. However, neither bilateral adrenalectomy nor bilateral nephrectomy alone inhibited jejunal absorption. Furthermore, inhibition of angiotensin formation in adrenalectomized animals failed to alter jejunal absorption. Decreased jejunal absorption in high-Na animals is not due to volume expansion or to inhibition of the renin-angiotensin-aldosterone axis. |
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Authors:
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N R Levens |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 251 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1986-10-20 Completed Date: 1986-10-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G413-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Aldosterone / blood Animals Blood Volume / drug effects Captopril / pharmacology Diet Enalapril / pharmacology Extracellular Space / drug effects, physiology* Intestinal Absorption / drug effects* Jejunum / physiology* Male Nephrectomy Rats Rats, Inbred Strains Renin / blood Serum Albumin, Bovine / pharmacology Sodium / administration & dosage, deficiency, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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AM-30941/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin, Bovine; 52-39-1/Aldosterone; 62571-86-2/Captopril; 7440-23-5/Sodium; 75847-73-3/Enalapril; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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