Document Detail

Response of pulmonary vein potentials to premature stimulation.
MedLine Citation:
PMID:  11843480     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Pulmonary vein potentials reflect depolarization of muscle fascicles within the myocardial sleeves that surround the pulmonary veins. The response of pulmonary vein potentials to premature stimulation has not been described. METHODS AND RESULTS: In 31 patients with paroxysmal atrial fibrillation referred for segmental isolation of the pulmonary veins, programmed stimulation with a single atrial extrastimulus was performed from the coronary sinus. Bipolar and unipolar electrograms were recorded with a decapolar Lasso catheter positioned sequentially within the left superior, left inferior, and right superior pulmonary veins, near the ostium. Premature stimulation often resulted in greater separation of the atrial and pulmonary vein potentials recorded within the pulmonary veins, fractionation of the pulmonary vein potentials, a change in the circumferential activation sequence of the pulmonary vein potentials, and dropout of pulmonary vein potentials. CONCLUSION: In response to premature stimulation, the muscle fascicles within the myocardial sleeves that surround the pulmonary veins display a greater degree of decremental conduction than do the myocardial fibers in the adjacent left atrium, and they display heterogeneity in conduction properties and refractoriness. Discrimination of pulmonary vein potentials from atrial electrograms is facilitated by premature stimulation.
Hiroshi Tada; Hakan Oral; Mehmet Ozaydin; Radmira Greenstein; Frank Pelosi; Bradley P Knight; S Adam Strickberger; Fred Morady
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  13     ISSN:  1045-3873     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-14     Completed Date:  2002-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0022, USA.
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MeSH Terms
Electric Stimulation
Evoked Potentials / physiology
Heart Atria / physiopathology
Heart Conduction System / physiopathology
Middle Aged
Muscle, Smooth, Vascular / innervation,  physiology*
Myocardium / pathology
Pulmonary Veins / pathology,  physiology*
Tachycardia, Paroxysmal / physiopathology

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