Document Detail


Response of preterm infants to diphtheria-tetanus-pertussis vaccine.
MedLine Citation:
PMID:  3263614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The American Academy of Pediatrics recommendation that immunization of preterm infants with diphtheria-tetanus-pertussis (DTP) vaccine should begin at 2 months after birth, regardless of gestational age, is based on limited data. A prospective study was conducted to determine the immunogenicity and safety of DTP vaccine in preterm infants. One hundred ten preterm and 146 full term infants received doses of DTP at 2, 4 and 6 months after birth. Adjusted analysis of the antibody responses indicated that after three doses mean titers among preterm infants to each vaccine component were comparable to those of full term infants. Adjusted analysis of the incidence of adverse events indicated that the risk of adverse events in preterm infants was not significantly higher than that in full term infants. DTP vaccine is immunogenic and safe in preterm infants when the series is initiated at 2 months after birth, and this study supports the current recommendation of the American Academy of Pediatrics.
Authors:
B A Koblin; T R Townsend; A Muñoz; I Onorato; M Wilson; B F Polk
Related Documents :
15273444 - Benign b-cell precursors (hematogones) are the predominant lymphoid population in the b...
9214964 - Preterm infants and stress: a tool for the neonatal nurse.
17587854 - Glucose regulation in preterm newborn infants.
6870334 - Plasma 17-hydroxyprogesterone concentrations in ill newborn infants.
9445004 - Conservation of an intact vif gene of human immunodeficiency virus type 1 during matern...
22759234 - A dose-response relationship between fish consumption and human milk dha content among ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  7     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-12-21     Completed Date:  1988-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  704-11     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antibody Formation
Crying
Diphtheria Toxoid / adverse effects,  therapeutic use*
Diphtheria-Tetanus-Pertussis Vaccine
Drug Combinations / adverse effects,  therapeutic use
Female
Humans
Immunization Schedule
Infant
Infant, Newborn
Infant, Premature / immunology*
Male
Pertussis Vaccine / adverse effects,  therapeutic use*
Tetanus Toxoid / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Diphtheria Toxoid; 0/Diphtheria-Tetanus-Pertussis Vaccine; 0/Drug Combinations; 0/Pertussis Vaccine; 0/Tetanus Toxoid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regional brain glucose utilization in adenylosuccinase-deficient patients measured by positron emiss...
Next Document:  Reflex sympathetic dystrophy in children: treatment with transcutaneous electric nerve stimulation.