| Response of plasma endorphins, corticotropin, cortisol, and luteinizing hormone in the corticotropin-releasing hormone stimulation test in eumenorrheic and amenorrheic athletes. | |
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MedLine Citation:
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PMID: 1846825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared pituitary response in the corticotropin-releasing hormone (CRH) test between 9 eumenorrheic and 10 amenorrheic endurance athletes. The maximal oxygen capacity (VO2max), determined using an exercise test on a bicycle ergometer, was larger in amenorrheic (62.7 +/- 1.0 SE mL/min per kg) than in eumenorrheic (54.7 +/- 2.3 mL/min per kg) athletes. A 100 micrograms bolus of human CRH was administered intravenously, and blood samples were collected at -15, 0, 30, 60, 90, and 120 minutes. The mean basal concentrations of endorphins, adrenocorticotropic hormone (ACTH), and cortisol did not show significant differences between the groups. The cumulative response of ACTH in the CRH test was larger in eumenorrheic (7.7 +/- 1.3 pmol/L) than in amenorrheic (3.6 +/- 0.6 pmol/L) athletes, but the response of endorphins and cortisol did not differ between the groups. A negative correlation was found between the VO2max and the ACTH response during the CRH test in the total group of athletes. These findings indicated changes in the function of hypothalamic-pituitary-adrenal axis in amenorrheic athletes that can be attributed to intensive training. |
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Authors:
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H Hohtari; K Salminen-Lappalainen; T Laatikainen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fertility and sterility Volume: 55 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-08 Completed Date: 1991-03-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 276-80 Citation Subset: IM |
Affiliation:
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Finnish Foundation of Exercise and Sports Medicine, Helsinki. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenocorticotropic Hormone / blood* Amenorrhea / blood* Corticotropin-Releasing Hormone / diagnostic use* Endorphins / blood* Female Humans Hydrocortisone / blood* Luteinizing Hormone / blood* Menstruation / blood* Physical Exertion Radioimmunoassay Reference Values Sports* |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9002-67-9/Luteinizing Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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