Document Detail


Response of plasma endorphins, corticotropin, cortisol, and luteinizing hormone in the corticotropin-releasing hormone stimulation test in eumenorrheic and amenorrheic athletes.
MedLine Citation:
PMID:  1846825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared pituitary response in the corticotropin-releasing hormone (CRH) test between 9 eumenorrheic and 10 amenorrheic endurance athletes. The maximal oxygen capacity (VO2max), determined using an exercise test on a bicycle ergometer, was larger in amenorrheic (62.7 +/- 1.0 SE mL/min per kg) than in eumenorrheic (54.7 +/- 2.3 mL/min per kg) athletes. A 100 micrograms bolus of human CRH was administered intravenously, and blood samples were collected at -15, 0, 30, 60, 90, and 120 minutes. The mean basal concentrations of endorphins, adrenocorticotropic hormone (ACTH), and cortisol did not show significant differences between the groups. The cumulative response of ACTH in the CRH test was larger in eumenorrheic (7.7 +/- 1.3 pmol/L) than in amenorrheic (3.6 +/- 0.6 pmol/L) athletes, but the response of endorphins and cortisol did not differ between the groups. A negative correlation was found between the VO2max and the ACTH response during the CRH test in the total group of athletes. These findings indicated changes in the function of hypothalamic-pituitary-adrenal axis in amenorrheic athletes that can be attributed to intensive training.
Authors:
H Hohtari; K Salminen-Lappalainen; T Laatikainen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  55     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-03-08     Completed Date:  1991-03-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  276-80     Citation Subset:  IM    
Affiliation:
Finnish Foundation of Exercise and Sports Medicine, Helsinki.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenocorticotropic Hormone / blood*
Amenorrhea / blood*
Corticotropin-Releasing Hormone / diagnostic use*
Endorphins / blood*
Female
Humans
Hydrocortisone / blood*
Luteinizing Hormone / blood*
Menstruation / blood*
Physical Exertion
Radioimmunoassay
Reference Values
Sports*
Chemical
Reg. No./Substance:
0/Endorphins; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9002-67-9/Luteinizing Hormone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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