| Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men. | |
| | |
MedLine Citation:
|
PMID: 18320358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL-6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96 +/- 6% lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P < 0.01) by 8.4 +/- 8.9 pg ml(-1) (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P < 0.05) by 2.7 +/- 3.9 ng ml(-1) (9.6%) and 37.7 +/- 55.6 ng ml(-1) (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130. |
| | |
Authors:
|
S R Gray; M Robinson; M A Nimmo |
Related Documents
:
|
15309008 - Is hormonal activation during exercise useful for risk stratification in patients with ... 3652408 - Norepinephrine kinetics during orthostatic stress in congestive heart failure. 10920088 - Three-dimensional endometrial volume estimation as a predictor of pituitary down-regula... 21697208 - Supporting community-based exercise in long-term neurological conditions: experience fr... 22607658 - Oral contraception and energy intake in women: impact on substrate oxidation during exe... 15169848 - Supplementation with vitamins c and e inhibits the release of interleukin-6 from contra... |
Publication Detail:
|
Type: Journal Article Date: 2008-03-05 |
Journal Detail:
|
Title: Cell stress & chaperones Volume: 13 ISSN: 1466-1268 ISO Abbreviation: Cell Stress Chaperones Publication Date: 2008 |
Date Detail:
|
Created Date: 2008-09-01 Completed Date: 2009-10-21 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9610925 Medline TA: Cell Stress Chaperones Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 247-51 Citation Subset: IM |
Affiliation:
|
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Volume Cytokine Receptor gp130 / biosynthesis, blood* Exercise Test Fatigue / blood Heart Rate Humans Interleukin-6 / biosynthesis, blood* Lactates / blood Male Middle Aged Motor Activity Oxygen Consumption Physical Exertion* Receptors, Interleukin-6 / biosynthesis, blood* Solubility |
| Chemical | |
Reg. No./Substance:
|
0/IL6 protein, human; 0/IL6R protein, human; 0/IL6ST protein, human; 0/Interleukin-6; 0/Lactates; 0/Receptors, Interleukin-6; 133483-10-0/Cytokine Receptor gp130 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic variation in heat shock protein 60 gene and coronary heart disease in China: tagging-SNP hap...
Next Document: P-Cadherin and beta-catenin are useful prognostic markers in breast cancer patients; beta-catenin in...