Document Detail

Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men.
MedLine Citation:
PMID:  18320358     Owner:  NLM     Status:  MEDLINE    
The pleiotropic cytokine interleukin-6 (IL-6) has been demonstrated to increase during exercise. Little is known regarding the response of the soluble IL-6 receptors (sIL-6R and sgp130) during such exercise. The aim of the current study was to investigate the response of plasma IL-6, sIL-6R and sgp130 during fatiguing submaximal exercise in humans. Twelve participants underwent an incremental exercise test to exhaustion and one week later performed a submaximal exercise bout (96 +/- 6% lactate threshold) to volitional exhaustion. Blood samples taken at rest and immediately post exercise were analyzed for IL-6, sIL-6R and sgp130. IL-6 increased (P < 0.01) by 8.4 +/- 8.9 pg ml(-1) (75.7%) during the exercise period. sIL-6R and sgp130 also increased (P < 0.05) by 2.7 +/- 3.9 ng ml(-1) (9.6%) and 37.7 +/- 55.6 ng ml(-1) (9.6%), respectively. The current study is the first investigation to demonstrate that alongside IL-6, acute exercise stress results in an increase in both sIL-6R and sgp130.
S R Gray; M Robinson; M A Nimmo
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Publication Detail:
Type:  Journal Article     Date:  2008-03-05
Journal Detail:
Title:  Cell stress & chaperones     Volume:  13     ISSN:  1466-1268     ISO Abbreviation:  Cell Stress Chaperones     Publication Date:  2008  
Date Detail:
Created Date:  2008-09-01     Completed Date:  2009-10-21     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  9610925     Medline TA:  Cell Stress Chaperones     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  247-51     Citation Subset:  IM    
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
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MeSH Terms
Blood Volume
Cytokine Receptor gp130 / biosynthesis,  blood*
Exercise Test
Fatigue / blood
Heart Rate
Interleukin-6 / biosynthesis,  blood*
Lactates / blood
Middle Aged
Motor Activity
Oxygen Consumption
Physical Exertion*
Receptors, Interleukin-6 / biosynthesis,  blood*
Reg. No./Substance:
0/IL6 protein, human; 0/IL6R protein, human; 0/IL6ST protein, human; 0/Interleukin-6; 0/Lactates; 0/Receptors, Interleukin-6; 133483-10-0/Cytokine Receptor gp130

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