| Response of the oxygen uptake efficiency slope to orthotopic heart transplantation: lack of correlation with changes in central hemodynamic parameters and resting lung function. | |
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MedLine Citation:
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PMID: 17845931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recently, a new linear measure of ventilatory response to exercise, the oxygen uptake efficiency slope (OUES), was proposed in the evaluation of heart failure patients. No data are available on the response of the OUES after orthotopic heart transplantation (HTx). METHODS: Thirty patients who underwent HTx between 1999 and 2003 were included in the study. Data from maximal cardiopulmonary exercise test, resting pulmonary function and hemodynamic assessment were collected before the transplant at time of screening and 1 year after HTx. RESULTS: During the first year after HTx, OUES and normalized OUES for body weight (OUES/kg) increased significantly from 15.6 +/- 4.9 to 19.7 +/- 4.8 (p < 0.05). Changes in OUES/kg were significantly correlated with changes in peak VO2, VAT and peak VE, and inversely to changes in peak VD/VT, but not to changes in VE/VCO2 slope (all p < 0.05). Changes in OUES or OUES/kg did not correlate with any changes in measures of resting lung volumes or capacities and measures of central hemodynamic function after HTx. CONCLUSIONS: OUES improved significantly after HTx, but, similar to other exercise parameters, remained considerably impaired. The changes in OUES were highly correlated with the improvements in other exercise variables, but did not correlate with marked improvements in central hemodynamics or resting lung function. |
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Authors:
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Christophe Van Laethem; Marc Goethals; Sofie Verstreken; Maarten Walravens; Francis Wellens; Margot De Proft; Jozef Bartunek; Marc Vanderheyden |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 26 ISSN: 1557-3117 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-11 Completed Date: 2007-10-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 921-6 Citation Subset: IM |
Affiliation:
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Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium. kine.van.laethem@telenet.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiovascular Physiological Phenomena* Exercise Test* Female Heart Transplantation* Humans Male Middle Aged Oxygen Consumption* Respiratory Physiological Phenomena* Rest |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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