Document Detail

Response of mouse sarcoma-180 to cis-platin in combination with radiation & hyperthermia.
MedLine Citation:
PMID:  8707373     Owner:  NLM     Status:  MEDLINE    
The in vivo response of a transplantable mouse tumour, sarcoma-180, to cis-platin (cDDP, 1.0, 2.5 or 5.0 mg/kg b.wt), local hyperthermia (HT, 42 degrees C, 30' or 60' and 43 degrees C, 30') and irradiation (RT, 10 Gy) was assessed on the basis of tumour cure (complete response, CR), volume doubling time (VDT) and regrowth delay (RD) as well as animal survival up to 120 days. Each agent was given as a single modality or in different combination regimens. A single injection of cDDP produced a dose dependent increase in all the parameters. Of all the single treatments, HT at 43 degrees C, 30' gave the maximum tumour cure. Combination of any of the two treatments resulted in a better response than all the single treatments. The chemosensitizing effect of heat was more pronounced than its radiosensitizing effect. Combination of all the three modalities, cDDP (2.5 mg/kg) + RT + HT (43 degrees C, 30') resulted in 100 per cent CR, without any local recurrence. This treatment also resulted in a significant increase in 120 day tumour free survival compared to all single modality treatments and bimodality treatments, except cDDP + 43 degrees C, 30'. This study indicates a potential advantage of the trimodality approach over single and bimodality treatments in the local control of solid tumours.
B S Rao; P U Devi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  103     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-09-11     Completed Date:  1996-09-11     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  315-22     Citation Subset:  IM    
Department of Radiobiology, Kasturba Medical College, Manipal.
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MeSH Terms
Antineoplastic Agents / therapeutic use*
Cisplatin / therapeutic use*
Combined Modality Therapy
Hyperthermia, Induced*
Mice, Inbred BALB C
Neoplasm Transplantation
Sarcoma, Experimental / pathology,  radiotherapy*,  therapy*
Survival Analysis
Reg. No./Substance:
0/Antineoplastic Agents; 15663-27-1/Cisplatin

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