| Response of microbodies in Morris hepatoma 9618A to clofibrate. | |
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MedLine Citation:
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PMID: 169361 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regulation of the formation of microbodies in Morris hepatoma 9618A was studied by examination of the response of the organelles to clofibrate. The fine structures of microbodies in the hepatoma cells closely resembled those in hepatocytes of normal adult rats. In clofibrate-treated rats, the tumor cells showed a slight increase in the size of microbodies and in catalase activity; however, the tumor microbodies did not increase in number. In contrast, in adult clofibrate-treated rats and rats on the day of birth whose mothers received clofibrate during the gestation period, the hepatocytes showed microbodies that were greater in both number and size, and the catalase activity in the liver was definitely elevated. |
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Authors:
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H Tsukada; Y Mochizuki; M Itabashi; M Gotoh; H P Morris |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 55 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-11-26 Completed Date: 1975-11-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 153-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Carcinoma, Hepatocellular / enzymology, pathology* Catalase / metabolism Clofibrate / pharmacology* Female Liver Neoplasms / enzymology, pathology* Male Maternal-Fetal Exchange Microbodies / drug effects*, enzymology, ultrastructure Microscopy, Electron Organoids / drug effects* Pregnancy Rats Rats, Inbred BUF |
| Chemical | |
Reg. No./Substance:
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637-07-0/Clofibrate; EC 1.11.1.6/Catalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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