| Response of malignant scalp dermatofibrosarcoma to presurgical targeted growth factor inhibition. | |
| | |
MedLine Citation:
|
PMID: 19681684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dermatofibrosarcoma protuberans (DFSP) is an uncommon, locally aggressive, malignant cutaneous tumor that sparingly presents on the scalp. Dermatofibrosarcomas often result from the formation of a fusion oncogene on translocated or supernumerary ring chromosomes 17 and 22, causing the overexpression of PDGFRbeta driven by the COL1A1 promoter. Because of uncertainty surrounding appropriate treatment of aggressive scalp DFSP, the authors performed an extensive review of the available data from a MEDLINE (Ovid) search to describe the clinical presentation and treatment options for this rare tumor. Their search identified 39 different cases, including the illustrative case presented in this study. Adjuvant therapy for this malignant lesion is not universally established in the literature. In the present case, the authors successfully treated a locally invasive scalp DFSP with presurgical therapy that specifically inhibited the PDGFbeta receptor. Imatinib significantly shrank the DFSP tumor mass, reduced hypervascularity, reduced metabolic activity on PET scanning, and permitted a safe gross-total resection. Although wide excision and Mohs micrographic surgery remain the standard surgical treatments for DFSP, the authors illustrate that presurgical chemotherapeutic treatment by imatinib provides a critical adjunct to traditional therapy. |
| | |
Authors:
|
Austin K Mattox; Ankit I Mehta; Peter M Grossi; Thomas J Cummings; D Cory Adamson |
Related Documents
:
|
19440004 - Extraoperative functional mapping and staged resection of supratentorial tumors near el... 20617084 - Transventricular biopsy of brain tumor without hydrocephalus using neuroendoscopy with ... 16702164 - T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal ad... 7834584 - Limb salvage surgery: an advance in surgical technique. 9788614 - Suppression or elevation of cytosolic phospholipase a2 alters keratinocyte prostaglandi... 10625854 - Giant cell angiofibroma of the buccal mucosa. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of neurosurgery Volume: 112 ISSN: 1933-0693 ISO Abbreviation: J. Neurosurg. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-03 Completed Date: 2010-05-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: United States |
Other Details:
|
Languages: eng Pagination: 965-77 Citation Subset: AIM; IM |
Affiliation:
|
Preston Robert Tisch Brain Tumor Center, Duke Medical Center, Durham, North Carolina 27710, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antineoplastic Agents
/
therapeutic use* Chromosomes, Human, Pair 17 / genetics Chromosomes, Human, Pair 22 / genetics Collagen Type I / genetics Dermatofibrosarcoma* / drug therapy, genetics, surgery Epidermal Growth Factor / antagonists & inhibitors* Humans Male Middle Aged Neurosurgical Procedures / methods Piperazines / therapeutic use* Pyrimidines / therapeutic use* Receptor, Platelet-Derived Growth Factor beta / genetics Scalp Skin Neoplasms* / drug therapy, genetics, surgery Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 0/Collagen Type I; 0/Piperazines; 0/Pyrimidines; 0/collagen type I, alpha 1 chain; 152459-95-5/imatinib; 62229-50-9/Epidermal Growth Factor; EC 2.7.10.1/Receptor, Platelet-Derived Growth Factor beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonan...
Next Document: Safety of magnetic resonance imaging of deep brain stimulator systems: a serial imaging and clinical...