| Response of lipoprotein(a) levels to therapeutic life-style change in obese African-Americans. | |
| | |
MedLine Citation:
|
PMID: 14709370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Lipoprotein(a) (Lp(a)) is regarded as an independent risk factor for Atherosclerotic cardiovascular disease. The objectives of this study were: to determine the effects of diet and exercise on Lp(a) and to evaluate the relation of Lp(a) with the lipid profile (total serum cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol). Baseline Lp(a), body mass index (BMI) and the lipid profiles were measured in 343 Obese (BMI >30kg/m(2)) African-Americans. After a 3-month intervention of diet and exercise by 105 participants, their lipids were re-measured. Baseline Lp(a) levels ranged from 1.2 to 280mg/dl. Lp(a) was inversely associated with triglyceride (P<0.05). After the intervention, Lp(a) and HDL increased by a mean of 20 and 5%, respectively. Total cholesterol, triglycerides, LDL and BMI decreased by 7, 10, 11 and 8%, respectively. Women taking estrogen replacement had a negligible change in Lp(a) while participants taking HMG-CoA reductase inhibitors had an increase in Lp(a) levels by 30%. |
| | |
Authors:
|
Otelio S Randall; Habteab B Feseha; Kachi Illoh; Shichen Xu; Muluemebet Ketete; John Kwagyan; Carl Tilghman; Michelle Wrenn |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Atherosclerosis Volume: 172 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2004 Jan |
Date Detail:
|
Created Date: 2004-01-07 Completed Date: 2004-05-20 Revised Date: 2009-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 155-60 Citation Subset: IM |
Affiliation:
|
Howard University General Clinical Research Center, Howard University Hospital, 2041 Georgia Avenue, NW, Suite 4-West, Washington, DC 20060-0001, USA. osrandall@howard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult African Americans Aged Body Mass Index Child Cholesterol / blood Cholesterol, HDL / blood Diet, Reducing Estrogen Replacement Therapy Exercise Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology Life Style* Lipids / blood* Lipoprotein(a) / blood* Lipoproteins, LDL / blood Male Middle Aged Obesity / therapy* Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
|
2 M01 RR 10284/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, HDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipids; 0/Lipoprotein(a); 0/Lipoproteins, LDL; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The close relationship between postprandial remnant metabolism and insulin resistance.
Next Document: Urinary cyclic GMP excretion and blood pressure levels in a general population.