Document Detail


Response of life threatening dimenhydrinate intoxication to sodium bicarbonate administration.
MedLine Citation:
PMID:  1660938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This is a report of an intentionally administered overdose of dimenhydrinate to a 4 month-old infant who subsequently presented with status epilepticus, coma, and life threatening ventricular dysrhythmias. Initial toxicologic analysis of the serum by fluorescence polarization immunoassay was positive for tricyclic antidepressants. Repeat analysis of the serum at 6 hours post ingestion by gas chromatography mass spectrometry analysis defined diphenhydramine 4.8 micrograms/mL. The infant was managed with IV sodium bicarbonate as utilized in tricyclic antidepressant intoxication. The dysrhythmias resolved and the infant recovered without sequelae.
Authors:
M Farrell; M Heinrichs; J A Tilelli
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  29     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-01-17     Completed Date:  1992-01-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  527-35     Citation Subset:  AIM; IM    
Affiliation:
Division of Critical Care Medicine, Arnold Palmer Hospital for Children and Women, Orlando, FL 32806.
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac / chemically induced*
Bicarbonates / therapeutic use*
Child Abuse*
Dimenhydrinate / blood,  poisoning*
Gas Chromatography-Mass Spectrometry
Heart / drug effects
Humans
Infant
Male
Overdose / therapy
Sodium / therapeutic use*
Sodium Bicarbonate
Status Epilepticus / chemically induced*
Chemical
Reg. No./Substance:
0/Bicarbonates; 144-55-8/Sodium Bicarbonate; 523-87-5/Dimenhydrinate; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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