Document Detail

Response of life threatening dimenhydrinate intoxication to sodium bicarbonate administration.
MedLine Citation:
PMID:  1660938     Owner:  NLM     Status:  MEDLINE    
This is a report of an intentionally administered overdose of dimenhydrinate to a 4 month-old infant who subsequently presented with status epilepticus, coma, and life threatening ventricular dysrhythmias. Initial toxicologic analysis of the serum by fluorescence polarization immunoassay was positive for tricyclic antidepressants. Repeat analysis of the serum at 6 hours post ingestion by gas chromatography mass spectrometry analysis defined diphenhydramine 4.8 micrograms/mL. The infant was managed with IV sodium bicarbonate as utilized in tricyclic antidepressant intoxication. The dysrhythmias resolved and the infant recovered without sequelae.
M Farrell; M Heinrichs; J A Tilelli
Related Documents :
24735258 - Practices and recommendations in infant feeding and hiv prevention: the child's perspec...
2723248 - The ontogeny of the metabolic and endocrine stress response in the human fetus, neonate...
10212078 - Development of fat digestion in infancy.
25329138 - Diagnostic errors in the pediatric and neonatal icu: a systematic review.
24827948 - Association of respiratory distress syndrome and perinatal hypoxia with histologic chor...
24421668 - Does parental body mass index status modify the associations among birth weight, early ...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  29     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-01-17     Completed Date:  1992-01-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  527-35     Citation Subset:  AIM; IM    
Division of Critical Care Medicine, Arnold Palmer Hospital for Children and Women, Orlando, FL 32806.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arrhythmias, Cardiac / chemically induced*
Bicarbonates / therapeutic use*
Child Abuse*
Dimenhydrinate / blood,  poisoning*
Gas Chromatography-Mass Spectrometry
Heart / drug effects
Overdose / therapy
Sodium / therapeutic use*
Sodium Bicarbonate
Status Epilepticus / chemically induced*
Reg. No./Substance:
0/Bicarbonates; 144-55-8/Sodium Bicarbonate; 523-87-5/Dimenhydrinate; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Isolation and characterization of purified sarcoplasmic reticulum membranes from isolated adult rat ...
Next Document:  Biventricular down-regulation of beta-adrenergic receptors in right ventricular hypertrophy induced ...