Document Detail

Response inhibition and set shifting in patients with frontal lobe epilepsy or temporal lobe epilepsy.
MedLine Citation:
PMID:  16091308     Owner:  NLM     Status:  MEDLINE    
Patients with frontal lobe epilepsy (FLE), patients with temporal lobe epilepsy (TLE), and matched controls were administered a test of response inhibition and set shifting (switching) (Color Word Interference Test, CWIT). Patients with FLE were impaired relative to the controls across all conditions of the CWIT, with the FLE patients showing disproportionate impairment in the Inhibition and Inhibition/Switching conditions. In contrast, the TLE patients did not differ from controls. Further analysis of the patient groups revealed that patients with left FLE were impaired relative to those with right FLE, left TLE, and right TLE in the Inhibition condition. In the Inhibition/Switching condition, patients with left FLE and left TLE were impaired relative to their right-sided counterparts. Finally, performance by the TLE group in the Inhibition/Switching condition was correlated with seizure frequency. These data suggest that patients with FLE, but not TLE, show impaired inhibition and set shifting relative to controls. In addition, side of the seizure focus and seizure frequency may contribute to executive dysfunction in patients with epilepsy.
Carrie R McDonald; Dean C Delis; Marc A Norman; Spencer R Wetter; Evelyn S Tecoma; Vicente J Iragui
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-08-08
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  7     ISSN:  1525-5050     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-28     Completed Date:  2005-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  438-46     Citation Subset:  IM    
Veterans Administration San Diego Healthcare System, and Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
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MeSH Terms
Color Perception
Epilepsy, Frontal Lobe / psychology*
Epilepsy, Temporal Lobe / psychology*
Neuropsychological Tests
Psychomotor Performance / physiology
Set (Psychology)*
Grant Support

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