Document Detail

Response of individual serum free fatty acids to oral and intravenous glucose: relation to adipose tissue composition.
MedLine Citation:
PMID:  8286881     Owner:  NLM     Status:  MEDLINE    
The rate of oral glucose delivery determines whether serum total free fatty acids remain low (glucose sipping over 210 min) or rebound 120-180 min after initial suppression (via glucose bolus), but the response of individual serum free fatty acids to glucose ingestion is largely unknown. In this study, we measured the changes over 240 min in the levels of individual serum free and esterified fatty acids after bolus or sipped glucose ingestion and determined the extent to which the changes are related to abdominal subcutaneous adipose tissue composition. In eight healthy volunteers, 74% of the prolonged suppression of total serum free fatty acids resulting from sipping 50 g glucose over 210 min was caused by a decrease in free linoleic and oleic acids, whereas 92% of the rebound in total free fatty acids 240 min after consuming 50 g of glucose as a bolus was caused by increases in free oleic and linoleic acids. Two hundred forty minutes after the oral glucose, slower intravenous clearance of 5 g glucose was directly correlated to higher total serum free fatty acids and free stearic acid and higher oleic but lower linoleic acid in adipose tissue. We conclude that the net response of serum free fatty acids to an oral glucose load is mediated primarily by oleic and linoleic acids in a manner largely unrelated to adipose tissue composition.
S C Cunnane; D J Jenkins; T M Wolever
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  9     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    1993 Sep-Oct
Date Detail:
Created Date:  1994-02-24     Completed Date:  1994-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  423-9     Citation Subset:  IM    
Department of Nutritional Sciences, Faculty of Medicine, St. Michael's Hospital, Toronto, Canada.
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MeSH Terms
Adipose Tissue / chemistry*,  drug effects
Administration, Oral
Analysis of Variance
Fatty Acids, Nonesterified / analysis,  blood*
Glucose / administration & dosage,  pharmacology*
Infusions, Intravenous
Regression Analysis
Time Factors
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 50-99-7/Glucose
Erratum In:
Nutrition 1993 Nov-Dec;9(6):527

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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