| Response of hypertrophic heart myocardial glycogen to GIK and hypovolemic shock. | |
| | |
MedLine Citation:
|
PMID: 2943528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Glucose-insulin-potassium (GIK) given during myocardial ischemia or anoxemia results in improved myocardial function and augments energy reserves of myocardial glycogen (MG). Because many patients with heart disease also have myocardial hypertrophy, our purpose was to examine whether similar elevations in MG can occur in hypertrophic hearts with GIK administration and to study the effect of hypovolemic shock on those MG levels. Mongrel dogs (n = 5) with myocardial hypertrophy underwent serial myocardial biopsies of the left (LV) and right (RV) ventricles, and blood samples were followed by GIK infusion (14.5 ml/kg/hr) for 2 hr. after which the dogs were subjected to 2 hr of hypovolemic shock (mean arterial pressure = 40 mmHg). It was found that after GIK infusion MG was consistently elevated in both RV (.43 +/- .02 to .60 +/- .04 g%) and LV (.63 +/- .07 to .71 +/- .01 g%) and FFA declined (.20 +/- .05 to .05-.01 mEq/liter). The MG responded to hypovolemia by further significant elevations (RV 1.16 +/- .33; LV .82 +/- .17), as did FFA (.38 +/- .21). These results indicate that hypertrophic hearts can indeed respond to GIK infusion by increasing MG in both the RV and LV, as do normal hearts. These hearts then submitted to hypovolemic shock showed a further elevation of MG. The elevated insulin levels post-GIK resulted in suppression of FFA. Thus GIK administration may have a sparing effect on energy stores of the heart during hypovolemic shock, which could have clinical implications in the treatment of patients with hypertrophic myocardia. |
| | |
Authors:
|
C Wittnich; J L Trudel; R C Chiu |
Related Documents
:
|
17215988 - Iatrogenic cardiac herniation and torsion after surgery for a penetrating cardiac injury. 2821638 - Possible role of oxygen-derived, free radicals in cardiocirculatory shock. 15537498 - High-resolution optical mapping of intramural virtual electrodes in porcine left ventri... 20348028 - Tunnel propagation following defibrillation with icd shocks: hidden postshock activatio... 1516188 - Declining incidence of ventricular fibrillation in myocardial infarction. implications ... 21831398 - Incidence of various cardiac arrhythmias and conduction disturbances due to high dose i... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Circulatory shock Volume: 19 ISSN: 0092-6213 ISO Abbreviation: Circ. Shock Publication Date: 1986 |
Date Detail:
|
Created Date: 1986-10-21 Completed Date: 1986-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0414112 Medline TA: Circ Shock Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 423-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Glucose / metabolism Cardiomegaly / drug therapy*, metabolism Dogs Fatty Acids, Nonesterified / blood Female Glucose / therapeutic use* Glycogen / metabolism* Heart Ventricles / metabolism Insulin / blood, therapeutic use* Male Potassium / therapeutic use* Shock / drug therapy*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/glucose-insulin-potassium cardioplegic solution; 11061-68-0/Insulin; 50-99-7/Glucose; 7440-09-7/Potassium; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modulation of putative preneoplastic foci in exocrine pancreas of rats and hamsters. I. Interaction ...
Next Document: Limitation of myocardial ischemia by collateral circulation during sudden controlled coronary artery...