Document Detail

Response of hepatic mitochondrial redox state to oral glucose load. Redox tolerance test as a new predictor of surgical risk in hepatectomy.
MedLine Citation:
PMID:  2157376     Owner:  NLM     Status:  MEDLINE    
The redox tolerance test introduced in this article attempts to quantify the deterioration of hepatic mitochondrial energy metabolism by measuring the changes in arterial ketone body ratio in response to 75-g oral glucose loading, and is discussed in relation to its predictive value for assessing surgical risk in hepatectomy. The indicator, called redox tolerance index (RTI), represents a 100-fold cumulative enhancement of ketone body ratio relative to glucose level (100 x delta KBR/delta glucose). The redox tolerance index was significantly different between 31 liver cirrhotics and 10 normal volunteers (p less than 0.001). Subjects were divided into three classes (I: RTI greater than or equal to 1.0, II: 0.5 less than or equal to RTI less than 1.0, III: RTI less than 0.5). Postoperative mortality was significantly different among the three classes in 127 hepatic resections (chi 2 = 9.843, p less than 0.01). Of 97 hepatocellular carcinoma cases, major hepatic resections in class III showed significantly higher postoperative morbidity and mortality rates (p less than 0.05 and p less than 0.05, respectively). The present findings indicate that RTI based on redox theory is of potential value in predicting posthepatectomy outcome.
K Mori; K Ozawa; Y Yamamoto; A Maki; Y Shimahara; N Kobayashi; Y Yamaoka; K Kumada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of surgery     Volume:  211     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-04     Completed Date:  1990-05-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  438-46     Citation Subset:  AIM; IM    
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
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MeSH Terms
Carcinoma, Hepatocellular / surgery
Glucose Tolerance Test*
Hepatectomy / mortality*
Ketone Bodies / blood*
Liver Cirrhosis / surgery
Liver Function Tests / methods*
Liver Neoplasms / surgery
Middle Aged
Mitochondria, Liver / metabolism*
Preoperative Care
Risk Factors
Reg. No./Substance:
0/Ketone Bodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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