Document Detail

Response of the gustatory system to peripheral nerve injury.
MedLine Citation:
PMID:  1728574     Owner:  NLM     Status:  MEDLINE    
Peripheral taste nerve damage occurs as a result of disease and surgery. The response depends on the taste field affected and the species. Nerve regeneration is robust after the nerve is crushed or after it is cut if the severed ends are anastomosed. Taste buds, which appear after nerve regeneration, may be derived from dormant stem cells outside of taste buds or from remnants of taste buds that persist following denervation. Sprouting by intact taste nerves into denervated fields apparently does not occur. Regenerated primary afferents have taste response specificity, but it is unknown if neural response types are retained peripherally or centrally. Recent behavioral studies show specific deficits following loss of restricted taste fields in rodents, but little is known about recovery after nerve regeneration. Specific deficits have not been demonstrated in humans, although taste sensitivity has been correlated with numbers of taste buds. Enigmas such as these may be solved once the response of the central nervous system to gustatory nerve injury is defined.
M A Barry; M E Frank
Related Documents :
8595764 - Malignant granular cell tumor mimicking herniated nucleus pulposus.
20553614 - Confocal analysis of nervous system architecture in direct-developing juveniles of nean...
3795194 - Peripheral nerve injection injury: an experimental pilot study of treatment modalities.
6255694 - Effects of perineurally applied cytostatic, cytotoxic and chelating agents upon periphe...
22166204 - Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubi...
1271494 - The pathophysiology of acute electric injuries.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Experimental neurology     Volume:  115     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-03     Completed Date:  1992-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  60-4     Citation Subset:  IM    
Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / cytology,  physiology
Chorda Tympani Nerve / injuries,  physiology*
Nerve Crush
Nerve Regeneration*
Taste / physiology
Taste Buds / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ablation of the olfactory bulb up-regulates the rate of neurogenesis and induces precocious cell dea...
Next Document:  Control of vertebrate retinal cell production.