Document Detail


Response of the gustatory system to peripheral nerve injury.
MedLine Citation:
PMID:  1728574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral taste nerve damage occurs as a result of disease and surgery. The response depends on the taste field affected and the species. Nerve regeneration is robust after the nerve is crushed or after it is cut if the severed ends are anastomosed. Taste buds, which appear after nerve regeneration, may be derived from dormant stem cells outside of taste buds or from remnants of taste buds that persist following denervation. Sprouting by intact taste nerves into denervated fields apparently does not occur. Regenerated primary afferents have taste response specificity, but it is unknown if neural response types are retained peripherally or centrally. Recent behavioral studies show specific deficits following loss of restricted taste fields in rodents, but little is known about recovery after nerve regeneration. Specific deficits have not been demonstrated in humans, although taste sensitivity has been correlated with numbers of taste buds. Enigmas such as these may be solved once the response of the central nervous system to gustatory nerve injury is defined.
Authors:
M A Barry; M E Frank
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Experimental neurology     Volume:  115     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-03     Completed Date:  1992-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  60-4     Citation Subset:  IM    
Affiliation:
Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / cytology,  physiology
Chorda Tympani Nerve / injuries,  physiology*
Nerve Crush
Nerve Regeneration*
Taste / physiology
Taste Buds / physiology*
Grant Support
ID/Acronym/Agency:
DC00168/DC/NIDCD NIH HHS; DC00853/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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