Document Detail

Response-guided therapy for patients with chronic hepatitis who have high viral loads of hepatitis C virus genotype 2.
MedLine Citation:
PMID:  22321126     Owner:  NLM     Status:  PubMed-not-MEDLINE    
AIM:   We evaluated the efficacy of response-guided therapy in patients with hepatitis C virus (HCV) genotype 2.
METHODS:   We studied 105 patients with an HCV genotype 2 load of higher than 5.0 Log IU/mL who received more than 75% of the target dose of pegylated interferon plus ribavirin. Among patients with rapid viral response (RVR; no HCV RNA detected at week 4), 14 selected 16 weeks of therapy (group A), and 28 selected 24 weeks of therapy (group B). Among non-RVR patients, 40 selected 24 weeks of therapy (group C), and 19 selected 48 weeks of therapy (group D).
RESULTS:   All patients in group A and B achieved a sustained viral response (SVR). Clinical characteristics did not differ significantly between groups C and D. However, the proportion of patients in whom HCV RNA disappeared at a later week after starting treatment was higher in group D (P = 0.0578). SVR rate was 73% in C, and 79% in D. Among patients in whom HCV RNA disappeared between weeks 5 and 8, SVR was achieved in 28 (82%) of 34 patients in C and 10 (91%) of 11 patients in D. Among patients whose HCV RNA disappeared between weeks 9 and 12, SVR was achieved in one (20%) of five patients in C and five (63%) of eight patients in D (not statistically significant).
CONCLUSIONS:   16 weeks of combination therapy could achieve an adequate antiviral effect for RVR patients. Extending therapy could not significantly improve SVR rate in non-RVR patients.
Yasunori Yamaguchi; Akihiro Tamori; Yasuhito Tanaka; Shuji Iwai; Sawako Kobayashi; Hideki Fujii; Hiroyasu Morikawa; Atsushi Hagihara; Masaru Enomoto; Norifumi Kawada
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Publication Detail:
Type:  Journal Article     Date:  2012-02-09
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  42     ISSN:  1386-6346     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-09     Completed Date:  2013-07-04     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  549-57     Citation Subset:  -    
Copyright Information:
© 2012 The Japan Society of Hepatology.
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