Document Detail

Response of fibrinolytic proteins and endothelin 1 to venous occlusion in patients on chronic hemodialysis.
MedLine Citation:
PMID:  9434059     Owner:  NLM     Status:  MEDLINE    
The main purpose of the present study was to determine whether any abnormalities in the response of fibrinolytic activity to venous occlusion could be observed in patients undergoing chronic hemodialysis (HD patients). A 10-min venous occlusion test was performed in 13 HD patients and in 9 healthy subjects. The arm opposite to the arteriovenous fistula was occluded in HD patients. The following factors were measured: tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1), plasmin-alpha2-plasmin inhibitor complex (PIC), stabilized fibrin degradation product (D-dimer), and von Willebrand factor antigen determined by enzyme immunoassay, and endothelin 1 by radioimmunoassay with two antibodies. Preocclusion levels of PIC, D-dimer, von Willebrand factor, and endothelin 1 were significantly higher and those of t-PA significantly lower in HD patients than in controls. During the occlusion, there was a positive correlation between the percent changes in t-PA and von Willebrand factor and between those in von Willebrand factor and PIC. There was no correlation between percent and absolute changes during the occlusion in endothelin 1 and those in t-PA, PAI-1, PIC, D-dimer, or von Willebrand factor. There was no significant difference between HD patients and controls as to the percent changes in hematocrit, t-PA, PIC, D-dimer and von Willebrand factor. HD patients demonstrated a significantly greater percent change in PAI-1 than controls. The mechanism by which endothelin 1 is released in response to the occlusion appears to differ from that for t-PA, PAI-1, and von Willebrand factor. PAI-1 may be readily released in response to stimuli to blood vessels in HD patients.
S Tomura; R Ando; Y Chida; T Ida; Y Hirata; F Marumo; S Tsuchiya
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Nephron     Volume:  77     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1997  
Date Detail:
Created Date:  1998-02-12     Completed Date:  1998-02-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  394-8     Citation Subset:  IM    
Institute of Community Medicine, University of Tsukuba, Japan.
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MeSH Terms
Blood Vessels / physiology*
Endothelin-1 / metabolism*
Kidney Diseases / metabolism*,  therapy
Middle Aged
Plasminogen Activator Inhibitor 1 / metabolism*
Renal Dialysis / adverse effects*
Tissue Plasminogen Activator / metabolism*
von Willebrand Factor / metabolism
Reg. No./Substance:
0/Endothelin-1; 0/Plasminogen Activator Inhibitor 1; 0/von Willebrand Factor; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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