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Response features determining spike times.
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MedLine Citation:
PMID:  10714266     Owner:  NLM     Status:  MEDLINE    
Interpreting messages encoded in single neuronal responses requires knowing which features of the responses carry information. That the number of spikes is an important part of the code has long been obvious. In recent years, it has been shown that modulation of the firing rate with about 25 ms precision carries information that is not available from the total number of spikes across the whole response. It has been proposed that patterns of exactly timed (1 ms precision) spikes, such as repeating triplets or quadruplets, might carry information that is not available from knowing about spike count and rate modulation. A model using the spike count distribution, the low-pass filtered PSTH (bandwidth below 30 Hz), and, to a small degree, the interspike interval distribution predicts the numbers and types of exactly-timed triplets and quadruplets that are indistinguishable from those found in the data. From this it can be concluded that the coarse (< 30 Hz) sequential correlation structure over time gives rise to the exactly timed patterns present in the recorded spike trains. Because the coarse temporal structure predicts the fine temporal structure, the information carried by the fine temporal structure must be completely redundant with that carried by the coarse structure. Thus, the existence of precisely timed spike patterns carrying stimulus-related information does not imply control of spike timing at precise time scales.
B J Richmond; M W Oram; M C Wiener
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neural plasticity     Volume:  6     ISSN:  2090-5904     ISO Abbreviation:  Neural Plast.     Publication Date:  1999  
Date Detail:
Created Date:  2000-03-29     Completed Date:  2000-03-29     Revised Date:  2011-02-23    
Medline Journal Info:
Nlm Unique ID:  100883417     Medline TA:  Neural Plast     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  133-45     Citation Subset:  IM; S    
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, USA.
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MeSH Terms
Electrophysiology / methods
Fixation, Ocular
Geniculate Bodies / physiology*
Models, Statistical
Neurons / physiology*
Photic Stimulation
Poisson Distribution
Reaction Time / physiology*
Regression Analysis
Reproducibility of Results
Visual Cortex / physiology*
Visual Perception / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Neural Plast
Journal ID (publisher-id): NP
ISSN: 1687-5443
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright © 1999 .
Print publication date: Year: 1999
Volume: 6 Issue: 4
First Page: 133 Last Page: 145
ID: 2565320
DOI: 10.1155/NP.1999.133
PubMed Id: 10714266

Response Features Determining Spike Times
Barry J. RichmondI1I2*
Mike W. OramI1I2
Matthew C. WienerI1I2
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, USA
School of Psychology, St. Andrews University, Scotland, St. Andrews, , UK
Correspondence: *Barry J. Richmond

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