Document Detail


Response of the erythron and erythropoietin to autologous blood donations in paediatric subjects. Is erythropoietin supplement necessary?
MedLine Citation:
PMID:  9269066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study was undertaken to evaluate the need for erythropoietin (Epo) therapy to augment autologous blood collection in adolescents undergoing spinal corrective surgery. METHODS: We measured serum Epo and parameters of iron metabolism in 35 adolescents undergoing autologous blood collection for orthopaedic surgery. Ages of subjects ranged from 11 to 16 years (mean 15.5 years) with a female predominance. Generally, 10% of intravascular blood volume was collected once a week up to a total of three collections. RESULTS: There was an average 2.5-fold rise in serum Epo over the period of blood collection. Epo increased immediately after blood collection. There was a 1.4-fold rise in reticulocyte count, consistent with the Epo response, and an average of 1.5 units of red blood cells (200 ml/unit) being produced over this period. Despite this there was an average fall of 2 g/dl (15%) in haemoglobin level. Serum ferritin and transferrin saturation also fell. CONCLUSIONS: Paediatric subjects are able to donate the required units of blood as they have a good Epo response to mild anaemia. The amount of blood donated did not exceed their total mobilisable iron and the iron supplement was adequate for red cell synthesis.
Authors:
P Han; D Stacy
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Vox sanguinis     Volume:  73     ISSN:  0042-9007     ISO Abbreviation:  Vox Sang.     Publication Date:  1997  
Date Detail:
Created Date:  1997-10-02     Completed Date:  1997-10-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  24-7     Citation Subset:  IM    
Affiliation:
Department of Haematology, Women's and Children's Hospital, North Adelaide, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blood Donors*
Blood Transfusion, Autologous*
Child
Erythrocytes / physiology*
Erythroid Precursor Cells / physiology*
Erythropoietin / physiology*
Female
Humans
Linear Models
Male
Chemical
Reg. No./Substance:
11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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