| Response entropy increases during painful stimulation. | |
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MedLine Citation:
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PMID: 15840994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Frontal electromyography (FEMG) may increase during painful stimulation and indicate patient arousal. The Datex-Ohmeda Entropy Module calculates state entropy (SE) of the electroencephalogram (EEG; 0.8-32 Hz) and response entropy (RE) of EEG and FEMG (0.8-47 Hz). We determined whether RE increases above SE (RE--SE), an indication of FEMG, increase during painful stimuli and if this is related to paralysis or level of anesthesia. With the unanesthetized baseline measurement, SE was 89 +/- 2 and RE was 98 +/- 2. During paralysis and anesthesia with either 0.8% (n = 10) or 1.4% (n = 10) isoflurane, SE decreased to 63 +/- 7 and 34 +/- 14, respectively, and the RE--SE difference decreased 90%. Before recovery from paralysis, arterial catheter or head pin placement increased RE--SE above unanesthetized levels in eight patients (five treated with 0.8% and three with 1.4% isoflurane), consistent with an increase in FEMG. The elevated RE--SE difference was related to a significant increase in SE, blood pressure, and heart rate. After recovery from paralysis, tetanic stimulation of the ulnar nerve increased the RE--SE difference above unanesthetized levels in 8 of 20 patients (6 treated with 0.8% and 2 with 1.4% isoflurane). In these patients, SE increased significantly. The remaining 12 patients did not show an increase in RE--SE during tetanic stimulation and SE did not increase. We conclude that increased RE during painful stimulation was not dependent on recovery from paralysis but was seen more often in patients anesthetized with 0.8% compared with 1.4% isoflurane. This suggests that RE reflects FEMG and may be useful to identify inadequate anesthesia and patient arousal during painful stimuli. |
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Authors:
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Peggy Wheeler; William E Hoffman; Verna L Baughman; Heidi Koenig |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurosurgical anesthesiology Volume: 17 ISSN: 0898-4921 ISO Abbreviation: J Neurosurg Anesthesiol Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-20 Completed Date: 2005-06-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8910749 Medline TA: J Neurosurg Anesthesiol Country: United States |
Other Details:
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Languages: eng Pagination: 86-90 Citation Subset: IM |
Affiliation:
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Anesthesiology Department, University of Illinois at Chicago, Chicago, Illinois 60612, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arousal / physiology Blood Pressure / physiology Brain / physiopathology Electric Stimulation Electroencephalography Electromyography Entropy Female GABA Modulators / pharmacology Heart Rate / physiology Humans Male Midazolam / pharmacology Middle Aged Neurosurgical Procedures Pain / physiopathology* Spine / surgery |
| Chemical | |
Reg. No./Substance:
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0/GABA Modulators; 59467-70-8/Midazolam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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