Document Detail

Response of conductance and resistance vessels of the coronary artery to intracoronary isosorbide dinitrate in patients with variant angina.
MedLine Citation:
PMID:  8968794     Owner:  NLM     Status:  MEDLINE    
To elucidate the response of conductance and resistance vessels of the coronary artery after intracoronary isosorbide dinitrate (ISDN), we evaluated 11 patients with variant angina and 13 controls with a Doppler guidewire. Epicardial arterial diameter increased significantly after ISDN in patients with variant angina while it did not change significantly in the controls. Coronary diastolic flow velocity increased significantly in controls (p < 0.05), but was unchanged in patients with vasospastic angina. Coronary flow volume increased from 23.8 +/- 18.6 to 46.5 +/- 28.4 ml/min in patients with vasospastic angina as well as in the controls from 32.2 +/- 24.2 to 54.7 +/- 44.4 ml/min. Coronary resistance did not differ between the two groups before or after the injection of ISDN. Conductance vessels were dilated to a greater extent in the patients with variant angina. However, the response of resistance vessels did not differ significantly between the two groups.
T Yamada; M Okamoto; T Sueda; M Hashimoto; G Kajiyama
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  35     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-13     Completed Date:  1997-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  844-8     Citation Subset:  IM    
Department of Cardiology, Hiroshima Prefectural Hiroshima Hospital.
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MeSH Terms
Angina Pectoris, Variant / drug therapy,  physiopathology*
Blood Flow Velocity / drug effects
Coronary Circulation / drug effects
Coronary Vessels / drug effects*
Isosorbide Dinitrate / pharmacology*,  therapeutic use
Middle Aged
Vascular Resistance / drug effects*
Vasodilator Agents / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Vasodilator Agents; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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