| Response of conductance and resistance vessels of the coronary artery to intracoronary isosorbide dinitrate in patients with variant angina. | |
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MedLine Citation:
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PMID: 8968794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To elucidate the response of conductance and resistance vessels of the coronary artery after intracoronary isosorbide dinitrate (ISDN), we evaluated 11 patients with variant angina and 13 controls with a Doppler guidewire. Epicardial arterial diameter increased significantly after ISDN in patients with variant angina while it did not change significantly in the controls. Coronary diastolic flow velocity increased significantly in controls (p < 0.05), but was unchanged in patients with vasospastic angina. Coronary flow volume increased from 23.8 +/- 18.6 to 46.5 +/- 28.4 ml/min in patients with vasospastic angina as well as in the controls from 32.2 +/- 24.2 to 54.7 +/- 44.4 ml/min. Coronary resistance did not differ between the two groups before or after the injection of ISDN. Conductance vessels were dilated to a greater extent in the patients with variant angina. However, the response of resistance vessels did not differ significantly between the two groups. |
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Authors:
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T Yamada; M Okamoto; T Sueda; M Hashimoto; G Kajiyama |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 35 ISSN: 0918-2918 ISO Abbreviation: Intern. Med. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-03-13 Completed Date: 1997-03-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 844-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Hiroshima Prefectural Hiroshima Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris, Variant / drug therapy, physiopathology* Blood Flow Velocity / drug effects Coronary Circulation / drug effects Coronary Vessels / drug effects* Female Humans Isosorbide Dinitrate / pharmacology*, therapeutic use Male Middle Aged Vascular Resistance / drug effects* Vasodilator Agents / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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