Document Detail

Response of chronic renovascular hypertension to surgical correction or prolonged blockade of the renin-angiotensin system by two inhibitors in the rat.
MedLine Citation:
PMID:  6986225     Owner:  NLM     Status:  MEDLINE    
1. Removal of the renal artery constriction but not of the clipped kidney restored the blood pressure to normal levels in Goldblatt two-kidney rats with hypertension of more than 4 months' duration. 2. Despite the differences in blood pressure response, both surgical procedures lowered plasma renin concentration to normal or below normal values. 3. Administration of the oral converting enzyme inhibitor SQ 14 225 produced a marked fall in blood pressure in Goldblatt kidney rats with chronic hypertension. However, a prolonged infusion of the angiotensin II antagonist saralasin was quite ineffective. The difference in response to the two inhibitors may have been due to bradykinin potentiation by the converting enzyme inhibitor. 4. Although plasma renin is often elevated in Goldblatt two-kidney rats with hypertension of more than 4 months' duration, the renin-angiotensin system plays no role in the maintenance of blood pressure at this stage.
H Thurston; R F Bing; E S Marks; J D Swales
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  58     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-04-26     Completed Date:  1980-04-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  15-20     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / analogs & derivatives*
Blood Pressure / drug effects
Captopril / therapeutic use*
Chronic Disease
Hypertension, Renal / therapy*
Hypertension, Renovascular / blood,  physiopathology,  therapy*
Proline / analogs & derivatives*
Renin / blood
Saralasin / therapeutic use*
Reg. No./Substance:
11128-99-7/Angiotensin II; 147-85-3/Proline; 34273-10-4/Saralasin; 62571-86-2/Captopril; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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