Document Detail


Response characteristics of nasal trigeminal nociceptors in Gallus domesticus.
MedLine Citation:
PMID:  12060803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the chemoreceptive properties of the nasal trigeminal system are well known, the physiological characteristics of nasal nociceptors responding to both mechanical and chemical stimulation have not been well described. In this study, the activity of single nasal trigeminal units recorded from microdissected twigs of the ethmoidal nerve of anaesthetized hens (Gallus domesticus) was investigated. Using a mechanical search stimulus, 20 slowly and 22 rapidly adapting nasal mechanoreceptors were identified, exhibiting mean thresholds of 2.96 g. Twelve slowly adapting units also exhibited chemical sensitivity when exposed to ammonia gas. These had mean response thresholds of 0.232% vapour saturation and exhibited variable stimulus-response profiles. This is the first study to quantify the responses of polymodal nasal nociceptors to a noxious airborne chemical in any species.
Authors:
Dorothy E F McKeegan; Theodorus G M Demmers; Christopher M Wathes; R Bryan Jones; Michael J Gentle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  13     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-12     Completed Date:  2002-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  1033-5     Citation Subset:  IM    
Affiliation:
Welfare Biology Group, Roslin Institute, Roslin, Midlothian EH25 9PS.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Ammonia / diagnostic use
Animals
Chickens / anatomy & histology,  physiology*
Female
Mechanoreceptors / cytology,  physiology*
Nasal Cavity / innervation*,  physiology*
Nerve Fibers / physiology,  ultrastructure
Nerve Fibers, Myelinated / physiology,  ultrastructure
Neural Conduction / physiology
Nociceptors / cytology,  physiology*
Ophthalmic Nerve / cytology,  physiology*
Physical Stimulation
Reaction Time / physiology
Sensory Thresholds / physiology
Chemical
Reg. No./Substance:
7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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