| Response of central nervous system aspergillosis to voriconazole. | |
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MedLine Citation:
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PMID: 17921662 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fungal infections of the central nervous system (CNS) usually present as subacute meningitis. Other manifestations include mass effect and focal neurological deficits. Cerebrospinal fluid (CSF) examination and biopsy of the lesion are helpful in disclosing the organism involved. Aspergillosis presents as brain abscess or granuloma with predominant neutrophils in CSF. Voriconazole is a broad spectrum triazole antifungal agent. It can be given orally and has lesser adverse effects We report a 69-years-old diabetic male, with aspergilloma of para-nasal sinus invading the CNS, who responded well to voriconazole treatment. He discontinued the medication by himself as it was costly. Within a month of stopping the medication, he developed features of subacute meningitis. However he showed clinical improvement after the medication was restarted. The case is reported for the clinical evidence of antifungal activity of voriconazole against aspergillosis. |
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Authors:
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Prakash Balasubramaniam; Pranesh B Madakira; Anish Ninan; Aarthi Swaminathan |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neurology India Volume: 55 ISSN: 0028-3886 ISO Abbreviation: Neurol India Publication Date: 2007 Jul-Sep |
Date Detail:
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Created Date: 2007-10-08 Completed Date: 2009-06-09 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0042005 Medline TA: Neurol India Country: India |
Other Details:
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Languages: eng Pagination: 301-3 Citation Subset: IM |
Affiliation:
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Department of Neurology, PSG Institute of Medical Sciences and Research, Avinasi Road, Peelamedu, Coimbatore - 641 002, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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therapeutic use* Humans Male Middle Aged Neuroaspergillosis / drug therapy*, pathology Paranasal Sinuses / microbiology, pathology Pyrimidines / therapeutic use* Tomography, X-Ray Computed / methods Triazoles / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Pyrimidines; 0/Triazoles; 0/voriconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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