Document Detail

Response of central nervous system aspergillosis to voriconazole.
MedLine Citation:
PMID:  17921662     Owner:  NLM     Status:  MEDLINE    
Fungal infections of the central nervous system (CNS) usually present as subacute meningitis. Other manifestations include mass effect and focal neurological deficits. Cerebrospinal fluid (CSF) examination and biopsy of the lesion are helpful in disclosing the organism involved. Aspergillosis presents as brain abscess or granuloma with predominant neutrophils in CSF. Voriconazole is a broad spectrum triazole antifungal agent. It can be given orally and has lesser adverse effects We report a 69-years-old diabetic male, with aspergilloma of para-nasal sinus invading the CNS, who responded well to voriconazole treatment. He discontinued the medication by himself as it was costly. Within a month of stopping the medication, he developed features of subacute meningitis. However he showed clinical improvement after the medication was restarted. The case is reported for the clinical evidence of antifungal activity of voriconazole against aspergillosis.
Prakash Balasubramaniam; Pranesh B Madakira; Anish Ninan; Aarthi Swaminathan
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurology India     Volume:  55     ISSN:  0028-3886     ISO Abbreviation:  Neurol India     Publication Date:    2007 Jul-Sep
Date Detail:
Created Date:  2007-10-08     Completed Date:  2009-06-09     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0042005     Medline TA:  Neurol India     Country:  India    
Other Details:
Languages:  eng     Pagination:  301-3     Citation Subset:  IM    
Department of Neurology, PSG Institute of Medical Sciences and Research, Avinasi Road, Peelamedu, Coimbatore - 641 002, India.
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MeSH Terms
Antifungal Agents / therapeutic use*
Middle Aged
Neuroaspergillosis / drug therapy*,  pathology
Paranasal Sinuses / microbiology,  pathology
Pyrimidines / therapeutic use*
Tomography, X-Ray Computed / methods
Triazoles / therapeutic use*
Reg. No./Substance:
0/Antifungal Agents; 0/Pyrimidines; 0/Triazoles; 0/voriconazole

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