Document Detail

Response of asthmatics to methacholine and suggestion.
MedLine Citation:
PMID:  1247214     Owner:  NLM     Status:  MEDLINE    
Effects of diluent, methacholine, and suggestion on pulmonary function were studied in 9 asthmatic subjects. On day 1, flavored diluent was given as a control preparation. On day 2, increasing concentrations of similarly flavored methacholine were administered. On day 3, the effect of flavored diluent plus suggestion was studied. Although all variables were affected, the dose-response relationships for methacholine were most pronounced for specific airway conductance and airway resistance, in contrast to maximal mid-expiratory flow, forced expiratory volume in 1 sec, and forced vital capacity. Suggestion toward bronchoconstriction significantly affected only the plethysmographic parameters, specific airway conductance, and airway resistance, and not the spirometric variables. Both airway resistance and 1-sec forced expiratory volume showed slight, but significant, changes as a result of bronchodilator suggestion, which was used to overcome the suggestion toward bronchoconstriction. Because suggestion had a greater effect on large airways than peripheral airways, a role for the vagus is implied. Thus, any protocol using body plethysmography must consider a possible effect of suggestion on results.
S Spector; T J Luparello; M T Kopetzky; J Souhrada; R A Kinsman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  113     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  AIM; IM    
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MeSH Terms
Airway Resistance / drug effects
Amino Alcohols / diagnostic use*
Asthma / physiopathology*
Dose-Response Relationship, Drug
Forced Expiratory Volume
Isoetharine / diagnostic use*
Maximal Midexpiratory Flow Rate
Methacholine Compounds / diagnostic use*
Middle Aged
Phenylephrine / diagnostic use*
Respiration / drug effects*
Vital Capacity / drug effects
Reg. No./Substance:
0/Amino Alcohols; 0/Methacholine Compounds; 530-08-5/Isoetharine; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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