Document Detail

Response assessment in Waldenström macroglobulinaemia: update from the VIth International Workshop.
MedLine Citation:
PMID:  23150997     Owner:  NLM     Status:  Publisher    
This report represents a further update of the consensus panel criteria for the assessment of clinical response in patients with Waldenström macroglobulinaemia (WM). These criteria have been updated in light of further data demonstrating an improvement in categorical responses with new drug regimens as well as acknowledgement of the fact that such responses are predictive of overall outcome. A number of key changes are proposed but challenges do however remain and these include the variability in kinetics of immunoglobulin M (IgM) reduction with different treatment modalities and the apparent discrepancy between IgM and bone marrow/tissue response noted with some regimens. Planned sequential bone marrow assessments are encouraged in clinical trials.
Roger G Owen; Robert A Kyle; Marvin J Stone; Andy C Rawstron; Veronique Leblond; Giampaolo Merlini; Ramon Garcia-Sanz; Enrique M Ocio; Enrica Morra; Pierre Morel; Kenneth C Anderson; Christopher J Patterson; Nikhil C Munshi; Alessandra Tedeschi; Douglas E Joshua; Efstathios Kastritis; Evangelos Terpos; Irene M Ghobrial; Xavier Leleu; Morie A Gertz; Stephen M Ansell; William G Morice; Eva Kimby; Steven P Treon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  British journal of haematology     Volume:  -     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
St James's University Hospital, Leeds, UK.
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