Document Detail

Response of agranulocytosis to thymectomy in a patient with thymoma and chronic lymphocytic leukemia.
MedLine Citation:
PMID:  2913477     Owner:  NLM     Status:  MEDLINE    
A patient with chronic lymphocytic leukemia presented with recurrent episodes of severe neutropenia. This neutropenia was initially responsive to prednisone but eventually became refractory. A spindle-cell thymoma was diagnosed and resected with dramatic improvement in his granulocytopenia. Both autologous and heterologous granulocyte macrophage colony growth were clearly inhibited by the patient's serum. This is the first reported case of severe granulocytopenia associated with a thymoma that seemed to be reversed following thymectomy.
A B Weir; L W Dow
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medical and pediatric oncology     Volume:  17     ISSN:  0098-1532     ISO Abbreviation:  Med. Pediatr. Oncol.     Publication Date:  1989  
Date Detail:
Created Date:  1989-03-03     Completed Date:  1989-03-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7506654     Medline TA:  Med Pediatr Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  58-61     Citation Subset:  IM    
Department of Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee.
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MeSH Terms
Agranulocytosis / etiology*
Leukemia, Lymphocytic, Chronic, B-Cell / complications*
Middle Aged
Thymoma / complications*,  surgery
Thymus Neoplasms / complications*,  surgery

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