Document Detail

Response and adaptation of skeletal muscle to exercise--the role of reactive oxygen species.
MedLine Citation:
PMID:  17569613     Owner:  NLM     Status:  MEDLINE    
In the last 30 years, the role of reactive oxygen species (ROS) in exercise physiology has received considerable attention. Acute physical exertion has been shown to induce an augmented generation of ROS in skeletal muscle via different mechanisms. There is evidence that ROS formation in response to vigorous physical exertion can result in oxidative stress. More recent research has revealed the important role of ROS as signaling molecules. ROS modulate contractile function in unfatigued and fatigued skeletal muscle. Furthermore, involvement of ROS in the modulation of gene expression via redox-sensitive transcription pathways represents an important regulatory mechanism, which has been suggested to be involved in the process of training adaptation. In this context, the adaptation of endogenous antioxidant systems in response to regular training reflects a potential mechanism responsible for augmented tolerance of skeletal muscle to exercise-induced stress. The present review outlines current knowledge and more recent findings in this area by focussing on major sources of ROS production, oxidative stress, tissue damage, contractile force, and redox-regulated gene expression in exercising skeletal muscle.
Andreas Michael Niess; Perikles Simon
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-09-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  12     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-15     Completed Date:  2007-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4826-38     Citation Subset:  IM    
Medical Clinic, Department of Sports Medicine, University of Tuebingen, Germany.
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MeSH Terms
Adaptation, Physiological
Antioxidants / metabolism,  physiology
DNA Damage
Exercise Test
Lipid Peroxidation
Muscle, Skeletal / cytology,  metabolism,  physiology*
Oxidative Stress
Reactive Oxygen Species / metabolism*
Signal Transduction
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species

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