| Response rates to medical treatments and long-term clinical outcomes of nonsurgical patients with intestinal Behçet disease. | |
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MedLine Citation:
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PMID: 20054283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aims of this study were to evaluate the efficacy of medical treatments and to identify factors to predict clinical outcome of intestinal Behçet disease (BD) during medical treatment. METHODS: We performed a retrospective review of the medical records of 93 patients who were diagnosed and medically treated with intestinal BD at Severance Hospital, Seoul, Korea from 1992 to 2007. A therapeutic response was evaluated 8 weeks after the initiation of medical treatment, and cumulative recurrence and surgery rates were also assessed during long-term follow-up. RESULTS: The initial remission rate at 8 weeks after treatment was 66.7%. During the follow-up period, cumulative recurrence rates for intestinal BD were 24.9% at 2 years and 43.0% at 5 years. The recurrence rate was significantly higher in patients with apparent gastrointestinal symptoms at their initial presentation, volcano-type and deep intestinal ulcers, and those who failed to achieve complete remission during the initial treatment. Cumulative rates for surgery were 6.7% at 2 years and 15.1% at 5 years. The typical type of ulcers was the only predictive factor for the likelihood of surgery. CONCLUSIONS: Our study demonstrates that a considerable number of patients experience disease relapse during follow-up despite a high-remission rate after medical treatment for intestinal BD. Careful observation and intensive treatment should be carried out, especially in patients without complete remission after initial treatment, with deep and volcano-shaped ulcers, or with apparent gastrointestinal symptoms at the time of diagnosis. |
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Authors:
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Moon Jae Chung; Jae Hee Cheon; Seung Up Kim; Jae Jun Park; Tae Il Kim; Nam Kyu Kim; Won Ho Kim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 44 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-18 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: e116-22 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenal Cortex Hormones / administration & dosage Adult Aged Anti-Inflammatory Agents, Non-Steroidal / administration & dosage Azathioprine / administration & dosage Behcet Syndrome* / drug therapy, pathology, prevention & control, surgery Colchicine / administration & dosage Drug Therapy, Combination Female Humans Immunosuppressive Agents / administration & dosage Intestinal Diseases* / drug therapy, pathology, surgery Korea Male Mesalamine / administration & dosage Middle Aged Prognosis Recurrence Risk Factors Time Factors Treatment Outcome Ulcer* / drug therapy, pathology, surgery Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Immunosuppressive Agents; 446-86-6/Azathioprine; 64-86-8/Colchicine; 89-57-6/Mesalamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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