| The response of macrophages to a Cu-Al-Ni shape memory alloy. | |
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MedLine Citation:
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PMID: 20008088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cu-Al-Ni shape memory alloys (SMAs) have been investigated as materials for medical devices, but little is known about their biocompatibility. The aim of this work was to study the response of rat peritoneal macrophages (PMØ) to a Cu-Al-Ni SMA in vitro, by measuring the functional activity of mitochondria, necrosis, apoptosis, and production of proinflammatory cytokines. Rapidly solidified (RS) thin ribbons were used for the tests. The control alloy was a permanent mold casting of the same composition, but without the shape memory effect. Our results showed that the control alloy was severely cytotoxic, whereas RS ribbons induced neither necrosis nor apoptosis of PMØ. These findings correlated with the data that RS ribbons are significantly more resistant to corrosion compared to the control alloy, as judged by the lesser release of Cu and Ni in the conditioning medium. However, the ribbons generated intracellular reactive oxygen species and upregulated the production of IL-6 by PMØ. These effects were almost completely abolished by conditioning the RS ribbons for 5 weeks. In conclusion, RS significantly improves the corrosion stability and biocompatibility of Cu-Al-Ni SMA. The biocompatibility of this functional material could be additionally enhanced by conditioning the ribbons in cell culture medium. |
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Authors:
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Miodrag Colić; Sergej Tomić; Rebeka Rudolf; Ivan Anzel; Gorazd Lojen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-11 |
Journal Detail:
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Title: Journal of biomaterials applications Volume: 25 ISSN: 1530-8022 ISO Abbreviation: J Biomater Appl Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8813912 Medline TA: J Biomater Appl Country: England |
Other Details:
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Languages: eng Pagination: 269-86 Citation Subset: IM |
Affiliation:
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Institute of Medical Research, MMA, Crnotravska 17, 11002 Belgrade, Serbia. vmaimi@eunet.rs |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alloys
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chemistry,
metabolism* Aluminum / chemistry, immunology, metabolism* Animals Apoptosis Biocompatible Materials / chemistry, metabolism* Cell Survival Cells, Cultured Copper / chemistry, immunology, metabolism* Cytokines / immunology Macrophages / cytology*, immunology, metabolism Male Nickel / chemistry, immunology, metabolism* Peritoneum / cytology Rats Reactive Oxygen Species / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Alloys; 0/Biocompatible Materials; 0/Cytokines; 0/Reactive Oxygen Species; 7429-90-5/Aluminum; 7440-02-0/Nickel; 7440-50-8/Copper |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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