Document Detail


Response of Lactobacillus casei BL23 to phenolic compounds.
MedLine Citation:
PMID:  21951613     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aims:  To determine the inhibitory effect of phenolic compounds on Lactobacillus casei BL23, the role of two component signal transduction systems (TCS), and the response of Lact. casei BL23 to p-coumaric acid. Methods and Results:  Growth of Lact. casei BL23 and 17 derivative strains defective in each TCS harboured by this strain in the presence of p-coumaric acid, ferulic acid, caffeic acid or methyl gallate was monitored. Furthermore, changes in the protein content of Lact. casei BL23 when exposed to p-coumaric acid were evaluated by 2D-SDS PAGE. Eleven proteins differentially expressed in the presence of p-coumaric acid were detected. Six of them could be identified: ClpP and HtrA, involved in protein turnover and folding, acetyl-CoA carboxylase, involved in lipid metabolism, and an arginyl-tRNA synthetase were more abundant whereas PurL and PurN, involved in purine biosynthesis, were less abundant. Conclusions:  No significant differences were observed between the parental strain and the TCS-defective mutants. p-coumaric acid elicited a response against membrane and cytoplasmic damages. Significance and Impact of the Study:  The inhibitory effect of phenolic compounds on Lact. casei BL23 has been determined. For the first time, cytoplasmic proteins presumably involved in the response of Lact. casei BL23 against p-coumaric acid have been identified.
Authors:
Alba Rivas-Sendra; José María Landete; Cristina Alcántara; Manuel Zúñiga
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-27
Journal Detail:
Title:  Journal of applied microbiology     Volume:  -     ISSN:  1365-2672     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706280     Medline TA:  J Appl Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 The Society for Applied Microbiology.
Affiliation:
Departamento de Biotecnología de Alimentos, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), C/ Catedrático Agustín Escardino, 7, 46980 Paterna (Valencia), Spain.
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