Document Detail


Response of HT115, a highly invasive human colorectal adenocarcinoma cell line, to sodium butyrate treatment and glucose deprivation.
MedLine Citation:
PMID:  15703838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sodium butyrate or glucose deprivation induce a more differentiated phenotype in many cancer cells. The aim of this study was to determine whether the induction effect of butyrate and/or glucose deprivation is dependent, in some way, on the differentiation state of individual cell lines. Sodium butyrate enhanced alkaline phosphatase activity and induced formation of an ultrastructurally more differentiated phenotype in both HT29 and HT115 cell lines. Interestingly, the more invasive HT115 cells responded more strongly to butyrate treatment. On the other hand, the differentiation effect of glucose deprivation was much less prominent in the HT115 cell line in comparison with HT29 cells. Our data confirm the influence of the malignant potential of the cells on their response to treatment with differentiation and apoptosis-inducing agents. Butyrate treatment also enhanced the adhesiveness of HT115 cells. Since E-cadherin was not found in these cells, while the level of CEACAM1 was increased, it is obvious that the CEACAM1 molecules are involved in HT115 cell-cell adhesion.
Authors:
Jitka Stokrová; Vlasta Sovová; Eva Sloncová; Dana Kucerová; Zdena Tuhácková; Jan Korb
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of oncology     Volume:  26     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-10     Completed Date:  2005-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  793-9     Citation Subset:  IM    
Affiliation:
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 166 37 Praha 6, Czech Republic. sova@img.cas.cz
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / pathology*
Antigens, CD / pharmacology
Antigens, Differentiation / pharmacology
Butyric Acids / pharmacology*
Cell Adhesion
Cell Adhesion Molecules
Cell Differentiation
Colorectal Neoplasms / pathology*
Glucose / metabolism*
Humans
Neoplasm Invasiveness*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation; 0/Butyric Acids; 0/CD66 antigens; 0/Cell Adhesion Molecules; 50-99-7/Glucose; 79-31-2/isobutyric acid

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