Document Detail

Responding to toxic compounds: a genomic and functional overview of Archaea.
MedLine Citation:
PMID:  23276916     Owner:  NLM     Status:  MEDLINE    
Archaea occupy a considerable diversity of niches ranging from extreme of pH, salinity to temperature that cannot be tolerated by other forms of life. There is an increasing consciousness that they have a key role both on the biogeochemical cycling of elements and in the bioremediation of polluted habitat. A greater understanding of metal homeostasis and resistance to toxic compounds in this life domain is required to design new strategies for the bioremediation of contaminated sites. This review describes the strategies developed by Archaea to transform xenobiotic compounds and metal ions present in the environment. The adaptation and/or response to such chemicals and the molecular mechanisms of resistance evolved in Archaea are discussed.
Simonetta Bartolucci; Patrizia Contursi; Gabriella Fiorentino; Danila Limauro; Emilia Pedone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-89     Citation Subset:  IM    
Università degli Studi di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cinthia, Napoli, Italy.
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MeSH Terms
Adaptation, Physiological
Adenosine Triphosphatases / metabolism
Archaea / drug effects,  genetics,  physiology*
Biodegradation, Environmental
Environmental Pollution
Hydrocarbons, Aromatic / metabolism
Membrane Transport Proteins / genetics
Metabolic Detoxication, Drug*
Metals / metabolism,  toxicity*
Multidrug Resistance-Associated Proteins / genetics
Xenobiotics / toxicity*
Reg. No./Substance:
0/Hydrocarbons, Aromatic; 0/Membrane Transport Proteins; 0/Metals; 0/Multidrug Resistance-Associated Proteins; 0/Xenobiotics; EC 3.6.1.-/Adenosine Triphosphatases

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