Document Detail


Responding to her question: a review of the influence of pregnancy on HIV disease progression in the context of expanded access to HAART in sub-Saharan Africa.
MedLine Citation:
PMID:  19301115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 2007, sub-Saharan Africa was home to over half of all women living with HIV. The vast majority of these women are of reproductive age, which raises concerns about the high incidence of pregnancy. As access to antiretroviral treatment is rapidly scaled up, two important questions must be answered: (1) Does pregnancy impact HIV disease progression?; (2) Does pregnancy modify the highly active antiretroviral therapy (HAART) response on HIV disease progression? A systematic review of the biomedical literature was conducted and seven relevant studies were identified. To date, it appears that there is no effect of pregnancy on HIV disease progression. Furthermore, initial studies in high-income countries suggest that pregnancy may positively modify the HAART response. These findings, however, must be interpreted with caution as it remains unclear how other factors, such as adherence, may influence the relationship between pregnancy, HIV disease progression, and HAART.
Authors:
Sarah MacCarthy; Fatima Laher; Mzikazi Nduna; Lindiwe Farlane; Angela Kaida
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-03-20
Journal Detail:
Title:  AIDS and behavior     Volume:  13 Suppl 1     ISSN:  1573-3254     ISO Abbreviation:  AIDS Behav     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712133     Medline TA:  AIDS Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  66-71     Citation Subset:  IM    
Affiliation:
Department of Global Health and Population, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. smaccarthy@hsph.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Africa South of the Sahara
Antiretroviral Therapy, Highly Active*
Clinical Trials as Topic
Disease Progression
Female
HIV Infections / drug therapy*,  physiopathology*,  virology
HIV-1
Humans
Pregnancy
Pregnancy Complications, Infectious / drug therapy*,  physiopathology*,  virology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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