Document Detail

Respiratory viral infections in adults with and without chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  10903237     Owner:  NLM     Status:  MEDLINE    
A longitudinal cohort study of older adults with chronic obstructive pulmonary disease (COPD) who were stratified by FEV(1) at enrollment was done to define the etiology, frequency, severity, and medical-care impact of respiratory tract viral infections (RTVIs). Controls consisted of a group of subjects of comparable age with the patients. RTVIs were documented in 44% of observed acute respiratory illnesses in control subjects and in 27% of COPD subjects, who were followed for mean periods of 35 and 26 mo, respectively. In this heavily influenza-vaccinated cohort ( approximately 90% vaccinated each year), picornaviruses, parainfluenza viruses, and coronaviruses were most commonly identified. Mean time to return to clinical baseline was approximately 2 wk in each group. Control and COPD subjects with mild airways obstruction (baseline FEV(1) >/= 50% predicted) had few emergency-center visits or hospitalizations. Approximately half of COPD subjects with moderate/severe COPD (baseline FEV(1) < 50% predicted) had at least one emergency-center visit and/or hospitalization for acute respiratory illness. RTVIs were documented in 23% of hospitalizations and in 45% of patients admitted between December and March. RTVIs have a major impact on utilization of health care resources for COPD patients with moderate/severe airways obstruction.
S B Greenberg; M Allen; J Wilson; R L Atmar
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  162     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-13     Completed Date:  2000-09-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-73     Citation Subset:  AIM; IM    
Departments of Medicine and Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.
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MeSH Terms
Hospitalization / statistics & numerical data
Influenza Vaccines
Longitudinal Studies
Lung Diseases, Obstructive / complications*
Middle Aged
Respiratory Tract Diseases / complications*,  epidemiology,  prevention & control,  virology*
Time Factors
Virus Diseases / complications*,  epidemiology
Grant Support
Reg. No./Substance:
0/Influenza Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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