| Respiratory viral infections in adults with and without chronic obstructive pulmonary disease. | |
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MedLine Citation:
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PMID: 10903237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A longitudinal cohort study of older adults with chronic obstructive pulmonary disease (COPD) who were stratified by FEV(1) at enrollment was done to define the etiology, frequency, severity, and medical-care impact of respiratory tract viral infections (RTVIs). Controls consisted of a group of subjects of comparable age with the patients. RTVIs were documented in 44% of observed acute respiratory illnesses in control subjects and in 27% of COPD subjects, who were followed for mean periods of 35 and 26 mo, respectively. In this heavily influenza-vaccinated cohort ( approximately 90% vaccinated each year), picornaviruses, parainfluenza viruses, and coronaviruses were most commonly identified. Mean time to return to clinical baseline was approximately 2 wk in each group. Control and COPD subjects with mild airways obstruction (baseline FEV(1) >/= 50% predicted) had few emergency-center visits or hospitalizations. Approximately half of COPD subjects with moderate/severe COPD (baseline FEV(1) < 50% predicted) had at least one emergency-center visit and/or hospitalization for acute respiratory illness. RTVIs were documented in 23% of hospitalizations and in 45% of patients admitted between December and March. RTVIs have a major impact on utilization of health care resources for COPD patients with moderate/severe airways obstruction. |
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Authors:
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S B Greenberg; M Allen; J Wilson; R L Atmar |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 162 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-09-13 Completed Date: 2000-09-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 167-73 Citation Subset: AIM; IM |
Affiliation:
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Departments of Medicine and Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA. stepheng@bcm.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Hospitalization / statistics & numerical data Humans Influenza Vaccines Longitudinal Studies Lung Diseases, Obstructive / complications* Male Middle Aged Respiratory Tract Diseases / complications*, epidemiology, prevention & control, virology* Time Factors Virus Diseases / complications*, epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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N01AI15103/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Influenza Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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