| Respiratory variations in pulmonary and systemic blood flow in healthy humans. | |
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MedLine Citation:
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PMID: 22289157 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: Cardiovascular oscillations are tightly coupled to respiration. Respiratory sinus arrhythmia (RSA) is an important part of heart rate variability with unknown function. Stroke volumes from the right (r-SV) and left (l-SV) side of the heart are assumed to vary differently with respiration, but have not previously been recorded non-invasively and simultaneously in humans. The present study introduces an improved technique for capturing respiratory variations in r-SV. METHODS: Six young volunteers were investigated during spontaneous and metronome-paced breathing in the left lateral decubitus position. Heart rate (HR, from ECG), l-SV (from finger blood arterial pressure curve) and r-SV (pulsed ultrasound Doppler) were recorded. Left and right cardiac outputs (l-CO and r-CO) were calculated beat by beat from HR, l-SV and r-SV. Respiratory variations in cardiovascular variables and phase angles were estimated by spectral analysis at respiratory frequency (0.15-0.40 Hz). RESULTS: The amplitude of respiratory variations in l-CO were 17% of r-CO (94% CI (6%, 35%), P=0.03). The amplitude of the respiratory variations in l-SV was not different from r-SV (74%, 94% CI (50%, 127%) non-significant). Increases in HR and r-SV were in phase with inspiration, while l-SV decreased during inspiration. CONCLUSION: The amplitude of respiratory variations in l-CO is significantly smaller than in r-CO. Respiratory variations in HR and in l-SV are in inverse phase, thus RSA buffers respiratory variations in l-SV. RSA plays an important role in reducing oscillations in systemic blood flow resulting from respiratory changes in venous return. |
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Authors:
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Maja Elstad |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-31 |
Journal Detail:
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Title: Acta physiologica (Oxford, England) Volume: - ISSN: 1748-1716 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society. |
Affiliation:
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Department of Physiology Institute of Basic Medical Sciences, University of Oslo. |
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