| Respiratory tract allergic disease and atopy: experimental evidence for a fungal infectious etiology. | |
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MedLine Citation:
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PMID: 20807032 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Allergic asthma is an obstructive lung disease linked to environmental exposures that elicit allergic airway inflammation and characteristic antigen-specific immunoglobulin reactions termed atopy. Analyses of asthma pathogenesis using experimental models have shown that T helper cells, especially T helper type 2 (Th2) cells and Th2 cytokines such as interleukin 4 (IL-4) and IL-13, are critical mediators of airway obstruction following allergen challenge, but the environmental initiators of lung Th2 responses are less defined. Our studies demonstrate that fungal-derived proteinases that are commonly found in home environments are requisite immune adjuvants capable of eliciting robust Th2 responses and allergic lung disease in mice. We have further shown that common household fungi readily infect the mouse respiratory tract and induce both asthma-like disease and atopy to otherwise innocuous bystander antigens through the secretion of proteinases. These findings support the possibility that asthma and atopy represent a reaction to respiratory tract fungal infection, suggesting novel means for diagnosis and therapy of diverse allergic disorders. |
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Authors:
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Paul Porter; Sumanth Polikepahad; Yuping Qian; J Morgan Knight; Wen Lu; Wendy M-T Tai; Luz Roberts; Valentine Ongeri; Tianshu Yang; Alexander Seryshev; Stuart Abramson; George L Delclos; Farrah Kheradmand; David B Corry |
Publication Detail:
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Type: Journal Article Date: 2010-08-31 |
Journal Detail:
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Title: Medical mycology : official publication of the International Society for Human and Animal Mycology Volume: 49 Suppl 1 ISSN: 1460-2709 ISO Abbreviation: Med. Mycol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815835 Medline TA: Med Mycol Country: England |
Other Details:
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Languages: eng Pagination: S158-63 Citation Subset: IM |
Affiliation:
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Departments of Medicine, Pathology and Immunology, and Pediatrics, Baylor College of Medicine, Houston, TX, USA; School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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