Document Detail

Respiratory system model for quasistatic pulmonary pressure-volume (P-V) curve: inflation-deflation loop analyses.
MedLine Citation:
PMID:  18532869     Owner:  NLM     Status:  MEDLINE    
A respiratory system model (RSM) is developed for the deflation process of a quasistatic pressure-volume (P-V) curve, following the model for the inflation process reported earlier. In the RSM of both the inflation and the deflation limb, a respiratory system consists of a large population of basic alveolar elements, each consisting of a piston-spring-cylinder subsystem. A normal distribution of the basic elements is derived from Boltzmann statistical model with the alveolar closing (opening) pressure as the distribution parameter for the deflation (inflation) process. An error minimization by the method of least squares applied to existing P-V loop data from two different data sources confirms that a simultaneous inflation-deflation analysis is required for an accurate determination of RSM parameters. Commonly used terms such as lower inflection point, upper inflection point, and compliance are examined based on the P-V equations, on the distribution function, as well as on the geometric and physical properties of the basic alveolar element.
R Amini; U Narusawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  130     ISSN:  0148-0731     ISO Abbreviation:  J Biomech Eng     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-05     Completed Date:  2008-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  031020     Citation Subset:  IM    
Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, USA.
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MeSH Terms
Airway Resistance / physiology
Bionics / methods
Least-Squares Analysis
Lung Compliance / physiology
Lung Volume Measurements
Models, Biological*
Pulmonary Alveoli / physiology*
Reproducibility of Results
Research Design
Respiratory Mechanics / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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