Document Detail

Respiratory system mechanics in patients treated with isotonic or hypertonic NaCl solutions.
MedLine Citation:
PMID:  1623569     Owner:  NLM     Status:  MEDLINE    
Twenty-one patients who underwent elective surgery for coronary artery bypass were studied right after chest wall closure. They were anesthetized, paralyzed, and artificially ventilated with a constant-flow ventilator. Airflow, changes in lung volume, and tracheal pressure were measured. Respiratory system resistance (Rrs,max) was partitioned into its homogeneous (Rrs,min) and uneven (Rrs,u) components. Respiratory system elastance (Ers) was also measured. The subjects were randomly divided into two groups injected with test solutions just after chest wall closure: eleven patients received isotonic saline (0.9% NaCl solution), whereas the remaining ten were injected with hypertonic saline (7.5% NaCl solution). In all patients, mechanical parameters were measured at six different times: just before infusion, at 5 and 10 min (end of infusion); and at 15, 20, and 25 min after beginning of injection. No statistically significant differences were observed in respiratory system mechanical parameters between groups or between different times within each group. Our data suggest that hypertonic saline infusion does not result in significant changes in respiratory system mechanics in patients submitted to coronary artery bypass.
J O Auler; W A Zin; M A Martins; R N Younes; E M Negri; C Hoelz; M A Santos; R L Santos; M J Carvalho; P H Saldiva
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulatory shock     Volume:  36     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-08-10     Completed Date:  1992-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  243-8     Citation Subset:  IM    
Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, Brazil.
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MeSH Terms
Coronary Artery Bypass
Isotonic Solutions
Middle Aged
Respiratory Mechanics / drug effects*
Saline Solution, Hypertonic / pharmacology*
Sodium Chloride / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Isotonic Solutions; 0/Saline Solution, Hypertonic; 7647-14-5/Sodium Chloride

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