Document Detail

Respiratory system impedance with impulse oscillometry in healthy and COPD subjects: ECLIPSE baseline results.
MedLine Citation:
PMID:  21481577     Owner:  NLM     Status:  Publisher    
RATIONALE: Current assessment of COPD relies extensively on the use of spirometry, an effort-dependent maneuver. Impulse oscillometry (IOS) is a non-volitional way to measure respiratory system mechanics, but its relationship to structural and functional measurements in large groups of patients with COPD is not clear. OBJECTIVES: We evaluated the ability of IOS to detect and stage COPD severity in the prospective ECLIPSE cohort of COPD patients defined spirometrically, and contrasted with smoking and non-smoking healthy subjects. Additionally, we assessed whether IOS relates to extent of CT-defined emphysema. METHODS: We measured lung impedance with IOS in healthy non-smokers (n = 233), healthy former smokers (n = 322) or patients with COPD (n = 2054) and related these parameters with spirometry and areas of low attenuation in lung CT. MEASUREMENTS AND MAIN RESULTS: In healthy control subjects, IOS demonstrated good repeatability over 3 months. In the COPD group, respiratory system impedance was worse compared with controls as was frequency dependence of resistance, which related to GOLD stage. However, 29-86% of the COPD subjects had values that fell within the 90% confidence interval of several parameters of the healthy non-smokers. Although mean values for impedance parameters and CT indices worsened as GOLD severity increased, actual correlations between them were poor (r ≤ 0.16). CONCLUSIONS: IOS can be reliably used in large cohorts of subjects to assess respiratory system impedance. Cross-sectional data suggest that it may have limited usefulness in evaluating the degree of pathologic disease, whereas its role in assessing disease progression in COPD currently remains undefined.
Courtney Crim; Bartolome Celli; Lisa D Edwards; Emiel Wouters; Harvey O Coxson; Ruth Tal-Singer; Peter M A Calverley;
Related Documents :
20304187 - Dobutamine stress echocardiography in heart transplant recipients' evaluation: the role...
2240917 - Cardiovascular effects of the somatostatin analog octreotide in acromegaly.
18705707 - Description of self-reported fluid intake and its effects on body weight, symptoms, qua...
2963077 - Cardiomegaly and abdominal mass in an acromegalic patient.
25183077 - α:non-α and gγ:aγ globin chain ratios in thalassemia intermedia patients treated wi...
12950327 - Assessment of adipose tissue metabolism by means of subcutaneous microdialysis in patie...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-8
Journal Detail:
Title:  Respiratory medicine     Volume:  -     ISSN:  1532-3064     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
GlaxoSmithKline Research and Development, Research Triangle Park, NC, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clonality and phenotyping analysis of alveolar lymphocytes is suggestive of pulmonary MALT lymphoma.
Next Document:  Drug policy, harm and human rights: A rationalist approach.