Document Detail

Respiratory syncytial virus protects against the subsequent development of ovalbumin-induced allergic responses by inhibiting Th2-type γδ T cells.
MedLine Citation:
PMID:  23154879     Owner:  NLM     Status:  In-Data-Review    
Respiratory syncytial virus (RSV) infection has been hypothesized to be a risk factor for the development of allergy and asthma, but epidemiologic studies in humans still remain inconclusive. The association between RSV infection and allergic diseases may be dependent on an atopic background and previous history of RSV infection. It has been reported that RSV infection before sensitization to an allergen decreased the production of Th2-like cytokines in the lung and the levels of allergen-specific Th2-type antibodies in the serum. However, the underlying mechanisms are largely unknown. In the present study, the role of pulmonary γδ T cells in RSV-affected, allergen-induced airway inflammation was investigated. BALB/c mice were sensitized to or challenged with ovalbumin (OVA) and infected with RSV either before or after the sensitization period. It became clear that sensitization and challenge of mice with OVA induced a large influx of γδ T cells to the lungs. However, prior RSV infection inhibited the infiltration of γδ T cells as well as activated γδ T cells, characterized by expression of CD40L or CD69 molecular in the cell surface. Moreover, prior RSV infection elevated the type 1 cytokine gene expression but suppressed type 2 cytokine expression in the lung γδ T cells. Adoptive transfer of γδ T cells from OVA-sensitized and challenged mice increased airway inflammation, suggesting that γδ T cells may play a proinflammatory role in allergic responses. These results described here support the idea of an unknown γδ T cell-dependent mechanism in the regulation of RSV-affected, allergen-induced allergic airway responses. J. Med. Virol. 85:149-156, 2012. © 2012 Wiley Periodicals, Inc.
Leiying Zhang; Jing Liu; Enhua Wang; Bing Wang; Sheng Zeng; Jianqi Wu; Yoshinobu Kimura; Beixing Liu
Related Documents :
23597769 - Nuclear receptor expression patterns in murine plasmacytoid and conventional dendritic ...
24212999 - Inorganic arsenic induces apoptosis through downregulation of ube2d genes and p53 accum...
16843829 - Intrinsic disturbance of cellular redox balance enhances blood lymphocyte apoptosis in ...
24062519 - Sufficient production of geranylgeraniol is required to maintain endotoxin tolerance in...
23314569 - The role of candida albicans ap-1 protein against host derived ros in in vivo models of...
24646379 - Influence of the programmed cell death of lymphocytes on the immunity of patients with ...
18767949 - Targeting cytochrome p450 cyp1b1 with a therapeutic cancer vaccine.
9757589 - Uv light affects cell membrane and cytoplasmic targets.
23597769 - Nuclear receptor expression patterns in murine plasmacytoid and conventional dendritic ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  85     ISSN:  1096-9071     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-56     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Department of Immunology, School of Basic Medical Science, China Medical University, Shenyang, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Shedding of polyomavirus in the saliva of immunocompetent individuals.
Next Document:  Molecular characterization of serotype G9 rotaviruses circulating in South Korea between 2005 and 20...