Document Detail

Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response.
MedLine Citation:
PMID:  16210054     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Respiratory syncytial virus (RSV) infections during infancy are considered to be a risk factor for developing asthma and possibly allergic sensitization. OBJECTIVE: The aim of this study was to investigate the cytokines, chemokines, and eosinophil cationic protein in the nasopharyngeal secretions of infants < or = 7 months of age with RSV infections or other respiratory viral infections and healthy infants as controls. Groups were also analyzed according to age, < or = 3 months and >3 months, and the levels were compared within and between groups. RESULTS: Thirty-nine infants with RSV, 9 with influenza or parainfluenza virus infections and 50 controls with no history of infections, were enrolled in the study. The RSV-infected infants had significantly higher levels of IL-4; macrophage inflammatory protein 1beta, a chemoattractant for T cells; and eosinophil cationic protein in nasopharyngeal secretions compared with the control group. The levels of the TH2 cytokine IL-4 were significantly higher in RSV-infected infants < or = months of age compared with RSV-infected infants >3 months of age. In infants < or = 3 months of age, infections with influenza or parainfluenza virus caused TH2-like responses similar to those produced by RSV. CONCLUSION: Infections with RSV as well as with influenza and parainfluenza virus during early infancy preferentially promote a TH2-like response in the nose with local production of IL-4, IL-5, and macrophage inflammatory protein 1beta and infiltration and activation of eosinophils.
Sigurdur Kristjansson; Stefania P Bjarnarson; Göran Wennergren; Aslaug H Palsdottir; Thorgerdur Arnadottir; Asgeir Haraldsson; Ingileif Jonsdottir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  116     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-07     Completed Date:  2005-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  805-11     Citation Subset:  AIM; IM    
Children's Hospital Iceland, Reykjavik, Iceland.
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MeSH Terms
Age Factors
Case-Control Studies
Chemokines / metabolism
Cytokines / metabolism
Eosinophil Cationic Protein / metabolism
Infant, Newborn
Leukocyte Count
Respiratory Syncytial Virus Infections / blood,  immunology*
Respiratory Syncytial Virus, Human / immunology*,  pathogenicity*
Respiratory Tract Infections / blood,  immunology*,  virology
Th2 Cells / immunology*
Reg. No./Substance:
0/Chemokines; 0/Cytokines; EC 3.1.27.-/Eosinophil Cationic Protein; EC 3.1.27.-/RNASE3 protein, human

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