| Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response. | |
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MedLine Citation:
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PMID: 16210054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Respiratory syncytial virus (RSV) infections during infancy are considered to be a risk factor for developing asthma and possibly allergic sensitization. OBJECTIVE: The aim of this study was to investigate the cytokines, chemokines, and eosinophil cationic protein in the nasopharyngeal secretions of infants < or = 7 months of age with RSV infections or other respiratory viral infections and healthy infants as controls. Groups were also analyzed according to age, < or = 3 months and >3 months, and the levels were compared within and between groups. RESULTS: Thirty-nine infants with RSV, 9 with influenza or parainfluenza virus infections and 50 controls with no history of infections, were enrolled in the study. The RSV-infected infants had significantly higher levels of IL-4; macrophage inflammatory protein 1beta, a chemoattractant for T cells; and eosinophil cationic protein in nasopharyngeal secretions compared with the control group. The levels of the TH2 cytokine IL-4 were significantly higher in RSV-infected infants < or = months of age compared with RSV-infected infants >3 months of age. In infants < or = 3 months of age, infections with influenza or parainfluenza virus caused TH2-like responses similar to those produced by RSV. CONCLUSION: Infections with RSV as well as with influenza and parainfluenza virus during early infancy preferentially promote a TH2-like response in the nose with local production of IL-4, IL-5, and macrophage inflammatory protein 1beta and infiltration and activation of eosinophils. |
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Authors:
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Sigurdur Kristjansson; Stefania P Bjarnarson; Göran Wennergren; Aslaug H Palsdottir; Thorgerdur Arnadottir; Asgeir Haraldsson; Ingileif Jonsdottir |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 116 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-07 Completed Date: 2005-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 805-11 Citation Subset: AIM; IM |
Affiliation:
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Children's Hospital Iceland, Reykjavik, Iceland. sig@landspitali.is |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Case-Control Studies Chemokines / metabolism Cytokines / metabolism Eosinophil Cationic Protein / metabolism Eosinophils Female Humans Infant Infant, Newborn Leukocyte Count Male Respiratory Syncytial Virus Infections / blood, immunology* Respiratory Syncytial Virus, Human / immunology*, pathogenicity* Respiratory Tract Infections / blood, immunology*, virology Th2 Cells / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/Cytokines; EC 3.1.27.-/Eosinophil Cationic Protein; EC 3.1.27.-/RNASE3 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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