| Respiratory syncytial virus infections in autologous blood and marrow transplant recipients with breast cancer: combination therapy with aerosolized ribavirin and parenteral immunoglobulins. | |
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MedLine Citation:
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PMID: 11535995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Scant data are available concerning the impact and response to therapy of respiratory syncytial virus (RSV) infections in patients undergoing autologous blood and marrow transplantation (BMT) for breast cancer. During eight winter seasons from 1992-1993 to 1999-2000, nine (4%) of 249 such patients were hospitalized with RSV infections. Six patients, including all five patients who were early post transplant in the pre-engraftment period, developed pneumonia and were treated with a combination of aerosolized ribavirin and IVIG. Among five patients with pneumonia in whom therapy was initiated prior to respiratory failure, one (20%) died. The sixth patient, in whom therapy was initiated after respiratory failure developed, also died. In total, two (1%) patients, both of whom were in the pre-engraftment period, died of progressive pneumonia. In conclusion, RSV is a significant cause of life-threatening pneumonia in autologous BMT recipients with breast cancer during the early post-transplant period, and accounted for a substantial portion of the overall transplant-related mortality, which in recent years has been minimal. |
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Authors:
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S Ghosh; R E Champlin; N T Ueno; P Anderlini; K Rolston; I Raad; D Kontoyiannis; K Jacobson; M Luna; J Tarrand; E Whimbey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bone marrow transplantation Volume: 28 ISSN: 0268-3369 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-09-05 Completed Date: 2002-03-07 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: England |
Other Details:
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Languages: eng Pagination: 271-5 Citation Subset: IM |
Affiliation:
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Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Antineoplastic Combined Chemotherapy Protocols / administration & dosage, toxicity Antiviral Agents / administration & dosage Bone Marrow Transplantation / adverse effects, mortality Breast Neoplasms / complications*, therapy* Disease Progression Female Hematopoietic Stem Cell Transplantation / adverse effects*, mortality Humans Immunoglobulins, Intravenous / administration & dosage Pneumonia, Viral / chemically induced, drug therapy, mortality Respiratory Syncytial Virus Infections / chemically induced, drug therapy*, mortality Retrospective Studies Ribavirin / administration & dosage Survival Rate Transplantation, Autologous / adverse effects, mortality |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Antiviral Agents; 0/Immunoglobulins, Intravenous; 36791-04-5/Ribavirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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